方法：以“频繁眨眼”为主诉，诊断为异常瞬目征患儿为试验组。常规行视力、屈光学、裂隙灯、角膜荧光素染色、泪膜破裂时间检查，完善血铅及微量元素检查； 对照组为同时期内在我院儿童保健科以“健康查体”为主诉的患儿，且除外血铅浓度结果、其他体查结果均为正常的儿童。并按性别分为男童组及女童组。比较试验组与对照组血铅浓度的变化。

结果：试验组共371例，男295例，女76例，平均年龄为男6.56±2.41岁，女6.08±2.82岁。对照组共300例，男186例，女114例，平均年龄为男6.99±3.01岁，女6.56±2.80岁。试验组中男童平均血铅浓度为63.82±24.56μg/L，正常组中男童平均血铅浓度为53.98±15.42μg/L。试验组与正常组男童的血铅浓度比较，血铅浓度偏高，差异具有显著性统计学意义(χ²=16.96，P<0.01)。试验组中女童平均血铅浓度为56.96±16.69μg/L，正常组中女童平均血铅浓度为48.18±12.35μg/L。试验组与正常组女童的血铅浓度比较，差异不具有统计学意义(χ²=5.77，P=0.56)。正常组<3岁组平均血铅浓度为48.73±11.67μg/L，3～6岁组平均血铅浓度为51.39±14.87μg/L，>6岁组平均血铅浓度为52.98±14.45μg/L。试验组儿童3岁以下组平均血铅浓度为56.57±17.89μg/L，3～6岁组平均血铅浓度为59.92±18.46μg/L， 6岁以上组平均血铅浓度为67.00±32.55μg/L。其中0～3岁儿童试验组与对照组血铅浓度无统计学差异(χ²=3.54，P=0.17)。3～6岁年龄组及>6岁年龄组试验与对照组血铅浓度差异具有统计学意义(χ²=9.62，P=0.008； χ²=19.22，P=0.000)。将血铅浓度按<50，≥50μg/L且≤100μg/L，>100μg/L分为3个梯度，患儿出现异常瞬目发病率的相对危险度RR分为0.65，1.22，10.11。

结论：异常瞬目症患儿血铅浓度偏高，异常瞬目症发病率与血铅浓度成正相关。

METHODS: The patients with chief complaint of frequent eye blinking, whose diagnosis of abnormal eye blinking, were randomized to experimental group. The patients in this group carried out vision and the slit-lamp examination, detected corneal fluorescein staining and tear break-up time, and improved the level of blood lead and trace elements examination. The patients in control group with chief complaint of health physical examination in our hospital, excepted of blood lead level, the other body check results were normal and were divided into boys group and girls group according to the gender. The changes of the experimental group and control group in blood lead level were compared.

RESULTS: Totally 371 cases(male: 295 cases; female: 76 cases)with mean age was 6.56±2.41 years and 6.08±2.82 years respectively were in experimental groupe. In control group, there were 300 cases(male: 186 cases; female: 114 cases)with mean age was 6.99±3.01 years and 6.56±2.80 years respectively. The average of blood lead level of boys in experimental group was 63.82±24.56μg/L and 53.98±15.42μg/L in control group. The average of blood lead level in experimental group was higher than that in control group. The difference between of the two group was statistically significant(χ²=16.96, P<0.01). The average of blood lead level of girls in experimental group was 56.96±16.69μg/L and 48.18±12.35μg/L in control group. There was no difference between of the two group(χ²=5.77, P=0.56). In control group, the average of blood lead level with <3 years, 3～6 years and >6 years children were 48.73±11.67μg/L, 51.39±14.87μg/L,52.98±14.45μg/L respectively. In expirement group, the results were 56.57±17.89μg/L, 59.92±18.46μg/L and 67.00±32.55μg/L in <3, 3～6 and >6 children, respectively. There was no significant difference with <3 years(χ²=3.54, P=0.17). The difference with 3～6 years and >6 years children were statistically significant(χ²=9.62, P=0.008)and(χ²=19.22, P=0.000)respectively. The blood lead level were divided into three grades: <50μg/L, 50～100μg/L, >100μg/L, and relative risk(RR)were 0.65, 1.22, and 10.11 respectively.

CONCLUSION: Blood lead level of experimental group is higher than that of control group. The relationship between blood lead level and abnormal eye blinking in children is positive correlation.