方法：随机数字表法将224例VDT视疲劳患者分为滴眼液组、按摩组、合用组及对照组各56例，分别用七叶洋地黄双苷滴眼液治疗、眼局部穴位按摩治疗、七叶洋地黄双苷滴眼液与按摩联合治疗及常规用眼卫生指导，疗程4wk。以症状疗效指数、泪膜破裂时间(BUT)、泪液分泌试验(SⅠt)和角膜荧光素染色积分作为评价指标。

结果：(1)合用组症状疗效指数(78.96±5.29)%高于滴眼液组(69.55±6.23)%和按摩组(71.15±6.41)%，而滴眼液组和按摩组又高于对照组(33.01±4.26)%(P<0.01)； 七叶洋地黄双苷滴眼液、按摩的主效应及二者的交互作用对疗效指数的影响均有统计学意义(P<0.01)。(2)滴眼液组、按摩组、合用组干预后的BUT值和SⅠt值较干预前提高(P<0.05)； 干预后合用组BUT值大于滴眼液组、按摩组和对照组； 对照SⅠt值低于滴眼液组、按摩组及合用组。

结论：七叶洋地黄双苷滴眼液滴眼和眼局部穴位按摩均可显著改善VDT视疲劳患者的症状和眼生理状况，二者合用具有协同增效作用。

METHODS: Totally, 224 patients with VDT asthenopia were randomly divided into eye drops group(n=56)received the intervention by Esculin and Digitalisglycosides eye drops, acupoint massage group(n=56)received the intervention by acupoint massage around the eyes, and combination group(n=56)received the intervention by combination of both and control group received the intervention by ocular hygiene instruction. The effect was evaluated after 4wk. The symptoms curative effect index, tear film break-up time(BUT), Schirmer I test(SIt)and corneal fluorescein staining score were as the indexes of evaluation.

RESULTS: The symptoms curative effect index of combination group(78.96±5.29)% was higher than that of eye drops group(69.55±6.23)% and acupoint massage group(71.15±6.41)%, which of after both groups was higher than that of control group(33.01±4.26)%(P<0.01). The main effects of Esculin and Digitalisglycosides eye drops and acupoint massage and its interations for the curative effect index were statistically significant(P<0.01). BUT and SIt of after intervention in eye drops group were significantly higher than that of before intervention, acupoint massage group and combination group(P<0.05); After intervention, BUT of combination group was higher than that of eye drops group, acupoint massage group and control group; SIt of control group was lower than that of eye drops group, acupoint massage group and combination group.

CONCLUSION: Esculin and Digitalisglycosides eye drops and acupoint massage could improve symptoms and ocular physiology in patient with VDT asthenopia, and the effects of the combinative use of both are synergistic.