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[摘要]
目的：观察不同时间长度闭眼和睡眠后角膜地形图、角膜散光等的变化，研究闭眼以及睡眠造成的生理性缺氧对人眼角膜形态的影响。
方法：选取年龄22～33(26.19±3.95)岁的自愿者，排除屈光介质疾病及眼部其他疾病、无角膜接触镜配戴史等，共16例32眼，其中男10眼，女22眼。主要参数采用了Zeiss角膜地形图仪获取角膜模拟K值、角膜散光值、角膜表面不规则指数(CIM)和形状因子(SF)，测量时间点分别为：日间闭眼前、闭眼后10，20，30，60，120min； 夜间临睡前、超过6h的睡眠结束后，开眼立即检测、开眼后10，20，60，120min。
结果：闭眼过程中，人角膜地形图、角膜散光、CIM、SF等的变化差异无统计学意义。在超过6h的睡眠结束，开眼后过程中，人角膜地形图、角膜散光、CIM、SF等的变化差异无统计学意义。
结论：闭眼和睡眠没有构成对角膜实质性损伤，所以角膜地形和散光基本不变。
[Key word]
[Abstract]
AIM: To observe the changes of corneal topography and astigmatism
et al with various duration of closing eyes and sleep; and study the impact of closing eye and sleep causing physiological hypoxia on corneal topography.
METHODS: Sixteen volunteers were selected(32 eyes), 22-33(26.19 ± 3.95)years old, without refractive errors and other eye diseases, as well as never wearing corneal contact lens, including 10 male eyes and 22 female eyes. The main parameters received corneal simulation K value, corneal astigmatism, corneal irregular measure(CIM)and the shape factor(SF)by Zeiss corneal topographer. They were measured before and after closed eyes 10, 20, 30, 60, 120min; before sleep and after over 6h sleep, they were detected immediately as soon as they opened eyes after 10, 20, 60, 120min.
RESULTS: During closing eyes, there were no statistical significance on the changes of corneal topography, corneal astigmatism, and SF. After opening eyes and over 6h sleep, there were no statistical significance on the changes of corneal topography, corneal astigmatism, CIM, and SF.
CONCLUSION: Closing eyes and sleep don't injure the cornea substantially, so corneal topography and corneal astigmatism don't mainly change.
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