方法：纳入2010-10/2014-12于北京安贞医院确诊为单眼mCNV的患者30例。采用频域光学相干断层扫描(SD-OCT)，分别测量患眼与健眼黄斑中心凹下及其上方、下方、鼻侧、颞侧各1.5mm处的脉络膜厚度(SFCT，SCT_1.5mm，ICT_1.5mm，NCT_1.5mm，TCT_1.5mm)。屈光度、眼轴长度、黄斑中心凹下及不同位点的脉络膜厚度差异比较采用配对t检验。采用Logistic回归分析屈光度、眼轴长度、不同位点的脉络膜厚度与mCNV的关系。

结果：mCNV患眼与对侧健眼相比，眼轴长度与等效球镜度数的差异无统计学意义(P>0.05)。mCNV眼的ICT_1.5mm变薄(140.85±33.46μm)，与对侧眼相比(168.95±45.36μm)，差异有统计学意义(P=0.008)。Logistic回归分析显示，ICT_1.5mm变薄是mCNV的危险因素(OR=2.12； 95%CI：1.35～3.28； P=0.02)。

结论：ICT_1.5mm变薄可能是mCNV发生的危险因素。

METHODS: We prospectively recruited 30 cases of mCNV in Beijing Anzhen Hospital from October 2010 to December 2014. SD-OCT was used to measure choroidal thickness subfoveally and at 1.5mm superiorly, inferiorly, nasally and temporally(SFCT, SCT_1.5mm, ICT_1.5mm, NCT_1.5mm, TCT_1.5mm). Paired t-test was conducted to assess the difference of spherical equivalent, axial length and choroidal thickness between mCNV group and controls. Logistic regression analysis was performed to evaluate the correlation between spherical equivalent, axial length, choroidal thickness and mCNV.

RESULTS: The difference of spherical equivalent and axial length between mCNV group and controls was not significant(P>0.05). Inferior was decreased in mCNV group compared with controls(140.85±33.46μm vs 168.95±45.36μm). The difference was significant(P=0.008). Logistic regression demonstrated that decreased choroidal thickness(ICT_1.5mm)at inferior location was associated with mCNV(OR=2.12; 95%CI 1.35～3.28; P=0.02).

CONCLUSION: The decrease of ICT_1.5MM may be one of the risk factors of mCNV.