方法：检索中国学术期刊网(CNKI)、PubMed、Cochrane、Embase以及Web of Science数据库，使用随机效应模型，使用OR值及其95%可信区间评价SERPING1 rs2511989 基因多态性与AMD易感性的关联程度，同时对入选文献异质性，敏感性以及发表偏倚等进行评估。

结果：共纳入15项病例对照研究，收集8 657例AMD患者，对照组5 393例。各个遗传模型中均未发现SERPING1基因多态性与AMD发病具有相关性。(显性模型：OR=0.960，95%CI：0.918～1.003，P=0.009； 隐性模型：OR=0.898，95%CI：0.791～1.019，P=0.035； 共显性纯合模型：OR=0.881，95%CI：0.770～1.008，P=0.003； 共显性杂合模型：OR=0.962，95%CI：0.917～1.010，P=0.050)。但进一步研究发现SERPING1基因多态性与新生血管型AMD显著相关。(显性模型：OR=0.691，95%CI：0.547～0.872； 共显性纯合模型：OR=0.661，95%CI：0.450～0.971； 共显性杂合模型：OR=0.754，95%CI：0.589～0.964)。亚组分析未发现种族与国家对rs2511989基因多态性与AMD有影响。

结论：通常情况下SERPING1 rs2511989基因多态性与AMD无相关性，但在新生血管类型AMD可能与其存在相关性。期待更多研究来证实该假说。

METHODS: A random-effect Meta-analysis was performed. An electronic search was done in CNKI, PubMed, the Cochrane Collaboration's Database, Embase, and the ISI Web of Knowledge. Odds ratios(OR)and their 95% confidence interval(CI)were calculated to assess the strength of association between SERPING1 rs2511989 polymorphism and AMD susceptibility. Heterogeneity, sensitivity analysis and publication bias were also tested.

RESULTS: A total of 15 case-control studies with 8657 cases and 5393 controls were finally included in this Meta-analysis. There was no significant association between SERPING1 and AMD in all genetic models.(Dominant model: OR=0.960, 95%CI: 0.918-1.003, P=0.009; recessive model: OR=0.898, 95%CI: 0.791-1.019, P=0.035; homozygote model: OR=0.881, 95%CI: 0.770-1.008, P=0.003; heterozygote model: OR=0.962, 95%CI: 0.917-1.010, P=0.050). However, the associations between SERPING1 and neovascular AMD were significant in three models(dominant model: OR=0.691, 95%CI: 0.547-0.872; homozygote model: OR=0.661, 95%CI: 0.450-0.971; heterozygote model: OR=0.754, 95%CI: 0.589-0.964). Subgroup analysis by ethnicity and country did not find significant association between rs2511989 polymorphism and AMD susceptibility.

CONCLUSION: SERPING1 rs2511989 does not associates with AMD generally but may associate with neovascular AMD. More studies are required to verify the hypothesis.