方法：研究共纳入剥脱综合征患者60例86眼作为试验组，年龄相仿正常人55例89眼作为对照组。所有115例175眼均接受Schirmer泪试验及泪膜破裂时间试验，并对上方和鼻下方睑裂区球结膜进行印迹细胞学检查。印迹细胞学检查结果根据Nelson方法分级。对TBUT，Schirmer泪试验及印迹细胞学结果进行相关性分析。

结果：剥脱综合征患者的Schirmer试验、TBUT均较正常组显著降低，结膜细胞也有显著改变。剥脱综合征患者的印迹细胞学分级中位数为3级，而正常人组为0级。在试验组中发现45例样本出现了两种以上分级共存的现象，而对照组仅发现3例。此外，实验组中的45例样本结膜上皮细胞和杯状细胞分级出现明显差异，且均表现出杯状细胞的破坏甚于上皮细胞，而对照组未发现此种现象。

结论：剥脱综合征患者的结膜细胞受到破坏，泪液分泌受到影响，极易造成眼表疾病的出现。

METHODS: This study included 86 eyes of 60 patients with PEX and 89 eyes from 55 normal age-matched individuals. Tear film break-up time(TBUT), Schirmer's tests were performed and impression cytology(IC)specimens were obtained from upper and interpalpebral inferonasal bulbar conjunctiva for all 175 eyes of 115 cases. IC specimens were graded according to Nelson's method. The correlations between results of TBUT, Schirmer's test and the findings of impression cytology specimens were evaluated.

RESULTS: Patients with PEX had lower Schirmer's tests and TBUT and also revealed significant conjunctival cell alterations when compared with normal subjects. The median cytology scores were Grade 3 and Grade 0 in PEX patients and normal subject, respectively. Mixed involvement with more than one grade type change was observed in 45 specimens in cases with PEX and only in 3 specimens in the control cases. Besides, epithelial and goblet cell discordance was found in 45 specimens in the group with PEX which was not observed in the control group.

CONCLUSION: Destruction of conjunctival cytology combined with decreasing in tear tests demonstrates the presence of ocular surface disease in PEX.