方法：采用随机对照研究方法：观察组痉挛型脑瘫患儿30例其中痉挛型四肢瘫及双瘫各15例，对照组正常儿童30例，使用模式翻转视觉诱发电位观察半视野及全视野潜伏期及波幅的变化。

结果：全视野模式翻转视觉诱发电位研究观察组P100潜伏期为113.55±8.14ms ，P100波幅为23.08±15.41μV，对照组P100潜伏期为105.05±5.58ms，P100波幅为31.65±7.37μV，两组 P100潜伏期及P100波幅经比较，差异具有统计学意义(P<0.05)； 全视野模式翻转视觉诱发电位痉挛型双瘫P100潜伏期为112.73±7.22ms，P100波幅为21.03±12.17μV，痉挛型四肢瘫P100潜伏期为114.37±9.02ms，P100波幅为25.14±18.06μV。两组P100潜伏期及P100波幅经比较，差异没有统计学意义(P>0.05)； 观察组与对照组半视野模式翻转视觉诱发电位各眼各视野的比较，均存在统计学差异(P<0.05)，表现为观察组各眼各视野潜伏期均明显高于对照组； 全视野结合半视野模式翻转视觉诱发电位潜伏期的变化总结发生在视觉通路的病变：包括视神经病变，视神经部分病变，视交叉后病变和视交叉病变。其中以视交叉后病变较多见。

结论：模式翻转视觉诱发电位能有效了解痉挛型脑瘫患儿视觉障碍及损伤情况，以利于早期发现异常，早期干预。

METHODS: There were two groups in this study. 30 children with spastic cerebral palsy(quadriplegia: 15, diplegia: 15)were selected as observation group, while 30 normal children were selected as control group with randomized controlled trial. The changes of half-view and full-view incubation period and amplitude were observed by pattern reversal visual evoked potential.

RESULTS: Full-view pattern reversal visual evoked potential: the P100 incubation period of the observation group was 113.55±8.14ms, and the P100 amplitude was 23.08±15.41μV. The P100 incubation period of the control group was 105.05±5.58ms, and the P100 amplitude was 31.65±7.37μV. From the comparison on P100 incubation and P100 amplitude between two groups, the difference was statistically significant(P<0.05). P100 incubation period of the spastic diplegia of full-view pattern reversal visual evoked potential was 112.73±7.22ms, and the P100 amplitude was 21.03±12.17μV. P100 incubation period of the spastic quadriplegia was 114.37±9.02ms, and the P100 amplitude was 25.14±18.06μV. From the comparison on P100 incubation and P100 amplitude between two groups, the difference had no statistically significance(P>0.05). Compared to the control group, each eye and each view latency of observation group were higher, the difference was statistically significant(P<0.05). The change of the incubation period of the full-view and half-view pattern reversal visual evoked potential took place in the lesion of the visual pathway: including optic neuropathy, some optic nerve lesion, lesion after optic chiasma, and optic chiasma lesion. Among them, the lesion after the optic chiasma was the most common.

CONCLUSION: Pattern reversal visual evoked potential can help people to understand the visual impairment and injury of children with spastic cerebral palsy in order to identify the abnormal children and early intervention.