方法：应用optovue光学相干断层扫描仪分析37例45眼增殖前期糖尿病视网膜病变(preproliferative diabetic retinopathy，PPDR)和增殖期糖尿病视网膜病变(proliferative diabetic retinopathy，PDR)患者接受577nm全视网膜光凝术前和术后1，3，6mo黄斑中心凹视网膜神经上皮层的厚度。

结果：全视网膜光凝术后1，3mo，黄斑中心凹视网膜神经上皮层的厚度与术前相比较明显增厚，两者比较具有统计学差异(P<0.05)； 随访至术后6mo逐步恢复至光凝前的水平，没有统计学差异(P>0.05)。

结论：577nm全视网膜光凝术能够引起糖尿病患者黄斑中心凹神经上皮层厚度一过性增加，术后6mo时逐渐恢复到术前的水平。

METHODS: A total of 45 eyes of 37 cases suffering from preproliferative diabetic retinopathy(PPDR)and proliferative diabetic retinopathy(PDR)undergoing 577nm PRP were enrolled in this study. The alterations of the retinal thickness of macular fovea measured by optovue optical coherence tomography(OCT)before and 1, 3, 6mo following PRP were comparatively analyzed.

RESULTS: The macularfoveal retinal thickness after 1, 3mo of PRP had significantly increased that before operation(P<0.05). After 6mo postoperative follow-up, it gradually recovered to the level before PRP, with no significant difference(P>0.05).

CONCLUSION: After the treatment of PRP, it appeared a transient increase on the retinal thickness of macular fovea, but after 6mo following-up, the macular foveal retinal thickness decreased nearly to the levels before PRP.