方法：回顾性病例研究。对49例98眼LASIK术后发生屈光回退的患者行二次矫正手术。所有患者分成A、B组，A组24例48眼行LASIK手术，B组25例50眼行LASEK手术，术后1wk； 1mo； 1a，随访检查视力、屈光度、角膜曲率、总高阶像差值，采用成组t检验进行统计学处理。

结果：二次手术后1wk A、B组视力差异有统计学意义(P<0.05)。术后1mo两组视力差异无统计学意义(P>0.05)，术后1a A、B组裸眼视力、等效球镜屈光度、平均角膜曲率、总高阶像差值差异均无统计学意义(P>0.05)。LASIK组出现1例角膜上皮增生，LASEK组出现1例2级haze。

结论：采用LASIK或LASEK矫正LASIK术后屈光回退均安全、可靠。

METHODS:Forty-nine patients(98 eyes)with refractive regression after LASIK operation received the second surgery. All patients were divided into two groups: group A and B. Group A(48 eyes of 24 patients)received LASIK surgery and group B(50 eyes of 25 patients)received LASEK surgery. Inspect the main parameters included visual acuity, refraction, corneal curvature, and the total value of high-aberration after 1wk, 1mo and 1a, t-test of groups was used as statistical analysis method.

RESULTS: There was statistically significant(P<0.05)between the two groups in visual acuity after 1wk. There was no statistically significant between the two groups in visual acuity after 1mo, and there was also no statistically significant between the two groups in visual acuity, average spherical equivalent refractive degree, average corneal curvature, and the total value of high-aberration after one year(P>0.05). There developed one case of epithelium in growth after LASIK surgery, and one case of haze Ⅱ after LASEK surgery.

CONCLUSION: Both LASIK and LASEK surgery can obtain satisfactory therapeutic results after an unsuccessful LASIK surgery.