方法：将原发性开角型青光眼患者60例113眼随机分为两组，对照组和观察组各30例，分别为55眼和58眼，对照组滴用噻吗洛尔滴眼液，观察组患者滴用葛根素滴眼液治疗。比较两组间视力、视野、眼压的改善情况，比较治疗前后两组患者间视盘参数和房水中氧化应激相关指标差异。

结果：治疗后2，4wk，观察组视力和光敏度高于对照组，而眼压及视野缺损则小于对照组(P<0.05)，观察组盘沿面积、盘沿容积、视盘容积和杯盘水平径比显著高于对照组，而杯盘垂直径比则显著低于对照组(P<0.05)，观察组SOD，GSH-Px，TAC，CAT水平显著高于对照组，而MDA则显著低于对照组(P<0.05)。

结论：葛根素滴眼液可能通过抑制房水的氧化应激反应发挥降低青光眼患者眼压、提高其视力、改善视野缺失和视盘损伤的功效，葛根素滴眼液在青光眼治疗中具有积极意义。

METHODS: Sixty patients with glaucoma(113 eyes)were randomly divided into the control group(30 cases, 55 eyes). and the observation group(30 cases, 58 eyes). The patients in control group took based treatment, and those in observation group were treated by combined with puerarin eye drops. Then the disease-related visual acuity, visual field, intraocular pressure of two groups were compared, and optic disc parameters and antioxidant indexes capacity before and after treatment of two groups were also compared.

RESULTS: After 2, 6wk of treatment, the visual acuity and light sensitivity of observation group were higher than those of control group, while the intraocular pressure and visual field defect were smaller than those of control group(P<0.05); the rim area, rim volume, optic disc volume and horizontal diameter ratio cups of observation group were higher than those of control group, and the vertical diameter ratio cups was higher than that of control group(P<0.05); the levels of SOD, GSH-Px, TAC, CAT of observation group were all higher than those of control group, and the MDA was lower than that of control group(P<0.05).

CONCLUSION:Puerarin eye drops play the effect of reducing intraocular pressure and improving vision, the visual field loss and optic disc for patients with glaucoma through the inhibition of oxidative stress response of aqueous, and puerarin eye drops has positive significance in the treatment of glaucoma.