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[摘要]
目的：应用光学相干断层成像技术(OCT)测量比较阻塞性睡眠呼吸暂停(OSA)患者和正常对照人群的视网膜神经纤维层(RNFL)厚度，探讨视网膜神经纤维层厚度的减少与阻塞性睡眠呼吸暂停的相关性。
方法：计算机检索国内外数据库中关于使用OCT技术测量OSA患者与正常对照人群的RNFL厚度的临床对照试验、同时筛检纳入文献的参考文献。对符合纳入和排除标准的试验用Stata11.0软件进行Meta分析。
结果：纳入10项研究，共1488眼进行Meta分析。结果显示OSA患者的平均、上侧、鼻侧、下侧RNFL厚度相较正常对照组明显减少，加权均数差值分别为\〖-2.97，95%CI：(-4.65～-1.30)，P<0.01\〗、\〖-3.05，95%CI：(-4.93～-1.17)，P=0.002\〗、\〖-3.81， 95%CI：(-6.95～-0.68)，P=0.02\〗和\〖-4.16， 95%CI：(-7.63～-0.68)，P=0.02\〗。
结论：OSA患者相较正常人群出现了明显的RNFL厚度的减少，因此我们建议OSA患者需要常规进行OCT的RNFL厚度检查。
[Key word]
[Abstract]
AIM: To investigate the difference of retinal nerve fiber layer(RNFL)thickness measured with OCT between obstructive sleep apnea(OSA)patients and normal people and discuss the relativity between decresse of RNFL and OSA.
METHODS: The articles on the association of RNFL thickness and OSA were retrieved by searching international and national databases. The qualified articles were assessed by Meta-analysis with Stata11.0 software.
RESULTS: Totally 10 studies enrolled 1 488 eyes were included in the Meta-analysis. The results of Meta-analysis showed that in OSA patients, there was a significant average RNFL thickness reduction compared with the control group. There were significant differences in superior, nasal and inferior RNFL thickness between the two groups. WMD with a 95%CI were \〖-2.97, 95%CI:(-4.65～-1.30), P<0.01\〗, \〖-3.05, 95%CI:(-4.93～-1.17), P=0.002\〗, \〖-3.81, 95%CI:(-6.95～-0.68), P=0.02\〗, \〖-4.16, 95%CI:(-7.63～-0.68), P=0.02\〗 respectively.
CONCLUSION: RNFL thickness is reduced in OSA patients compared with the control group. OCT may become a standard part of the evaluation of patients in OSA.
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