[关键词]
[摘要]
小泛素相关修饰物(small ubiquitin related modifier，SUMO)修饰是一种蛋白翻译后修饰，又称为小泛素相关修饰或类泛素修饰，与目标蛋白共价结合调控细胞进程，如蛋白与蛋白之间的相互作用、蛋白与DNA之间的相互作用、转录因子的激活等。SUMO修饰能够升高或抑制靶蛋白转录活性，为研究真核细胞基因表达的调控提供了新线索。我们将近期SUMO修饰在眼科领域的研究进展做以综述。
[Key word]
[Abstract]
SUMOylation is a post-translational modification consisting of covalent conjugation of ubiquitin-like proteins called small ubiquitin related modifier(SUMO). SUMO modification has been shown to significantly alter protein activity, which can modulate protein stability, affect protein-protein interactions, and modify protein localization and trafficking.This process adds another layer of control in eukaryote gene expression, and it regulates both transcriptional activation and repression. This article reviews the current situation and future development of SUMOylation in ophthalmology.
[中图分类号]
[基金项目]
国家自然科学基金资助项目(No.81170836); 辽宁省自然科学基金资助项目(No.201202260)
