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[摘要]
目的：观察视网膜视盘周围视网膜神经纤维层(retina nerve fiber layer，RNFL)厚度和神经节细胞复合体(ganglion cell complex，GCC)厚度对慢性原发性闭角型青光眼(chronic primary angle-closure glaucoma，CPACG)的诊断价值，研究其和平均视野缺损(MD)的相关性。
方法：选取早期CPACG患者21例38眼，疑似青光眼(suspected glaucoma， SG)患者25例46眼和正常对照25例49眼进行SD-OCT检查，测量平均及各个象限的RNFL厚度和GCC厚度，分析RNFL厚度和GCC厚度与视野MD的相关性。
结果：CPACG组的平均和各象限RNFL厚度和GCC厚度与正常对照存在显著性差异(P<0.01)，与SG组比较，平均及上方(P<0.01)、下方(P<0.05)RNFL厚度存在显著性差异，平均和各象限GCC厚度存在显著性差异(P<0.01)。CPACG组RNFL(r=0.65)、GCC(r=0.72)均与MD呈明显的正相关。
结论：RNFL厚度和GCC厚度对早期CPACG的诊断和病情监测中具有临床价值，GCC厚度的临床意义可能更佳。
[Key word]
[Abstract]
AIM:To explore the diagnosis value of retina nerve fiber layer(RNFL)and ganglion cell complex(GCC)in the early stage of chronic primary angle-closure glaucoma(CPACG), and investigate their relationship with mean defect(MD)of visual field.
METHODS: Twenty-one patients with CPACG(38 eyes), 25 patients with suspected glaucoma(SG)(46 eyes)and 25 normal controls(49 eyes)were selected to perform SD-OCT. Statistical difference was analyzed the thickness of RNFL and GCC of average and all quadrants, and correlation between RNFL, GCC and MD of visual field.
RESULTS:There were significant differences in average and all quadrant thickness of RNFL and GCC between CPACG group and control group(P<0.01).The significant differences were found in RNFL thickness(RNFL-Avg, P<0.01; RNFL-Sup, P<0.01; RNFL-Inf, P<0.05)and in GCC thickness(average and all quadrant thickness, P<0.01)between CPACG group and SG group. The positive correlations were showed between MD and RNFL(r=0.65), GCC(r=0.72)in CPACG group.
CONCLUSION:RNFL and GCC are useful to diagnose and monitor the early stage of CPACG, and GCC may be more significant for the disease.
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