方法：将8～17岁儿童青少年99例165眼按屈光度分为正常对照组、低度近视组、中度近视组及高度近视组，应用Cirrus HD OCT分别对4组研究对象进行以视盘为中心，直径为3.46mm圆周的RNFL厚度测量，分别得出各组平均、各象限、各钟点RNFL厚度。将各近视组与正常组RNFL厚度进行比较，观察近视眼RNFL厚度变化特点。

结果：各近视组与正常组相比，平均RNFL厚度均变薄，高度近视组差异有统计学意义(P<0.05)，上、下、鼻侧象限RNFL厚度均变薄，颞侧象限厚度均变厚； 中度、高度近视组，上方、下方象限厚度变薄，差异有统计学意义(P<0.05)，颞侧象限厚度均变厚，差异有统计学意义(P<0.05)； 1：00，5：00，6：00，12：00位RNFL厚度变薄，差异有统计学意义(P<0.05)，8：00，9：00，10：00位RNFL厚度增加，差异有统计学意义(P<0.05)，低度近视3：00位RNFL厚度增加，差异有统计学意义(P<0.05)。

结论：儿童青少年近视眼与正常眼相比，Avg(平均RNFL厚度)，S(上方象限RNFL厚度)，I(下方象限RNFL厚度)，1：00，5：00，6：00，12：00位RNFL厚度变薄，且随着屈光度增加其RNFL厚度变薄，T(颞侧)，8：00，9：00，10：00位RNFL厚度变厚，且随着屈光度增加其RNFL厚度变厚。在对近视眼进行RNFL厚度测量时，发现有异常RNFL厚度变化时，应该考虑到屈光度的影响，综合评价其临床意义，以免造成对青光眼的误诊。对于青光眼诊断效能最高的颞下(7：00～8：00位)、颞上(10：00～11：00位)RNFL并未出现变薄，当对儿童青少年近视眼进行RNFL厚度测量时，如果出现上述方位的RNFL厚度变薄，应考虑青光眼的可能性，以免漏诊。

METHODS: A total of 165 eyes from 99 healthy subjects(age range 8～17 years)were divided into low, moderate, high myopia and normal group. Cirrus HD OCT was used to measure the RNFL thickness. Each subject was performed circular scans around the optic nerve with a circle size of 3.46mm. Total average, mean quadrant and clock-hour RNFL thicknesses were recorded and compared between the four groups. The characteristics of the RNFL thickness of myopia were observed.

RESULTS: Compared myopia groups with normal group, the mean RNFL thickness decreased, there was statistically significant difference in high myopia group(P<0.05). The mean RNFL thickness of superior, inferior and nasal quadrant decreased, temporal quadrant was thickened. Compared moderate and high myopia groups with normal group, superior, inferior quadrant RNFL thickness were thinning, temporal quadrant was thickening, the differences had statistical significance(P<0.05). The RNFL measurements were statistically significant thinner in the myopia groups compared with normal group at 1:00, 5:00, 6:00 and 12:00 o'clock(P<0.05)and thicker at 8:00, 9:00, 10:00 o'clock(P<0.05). The RNFL measurement was statistically significant thicker in the low myopia group compared with normal group at 3:00 o'clock(P<0.05).

CONCLUSION: Compared adolescent myopia with normal, the Avg(mean RNFL thickness), S(superior quadrant RNFL thickness), I(inferior quadrant RNFL thickness), 1:00, 5:00, 6:00 and 12:00 o'clock RNFL thickness is thinner, which is decreased with the increasing SE. While the temporal(T)quadrant, 8:00, 9:00, 10:00 o'clock RNFL thickness is thicker, which increased with the increasing SE. Analysis of RNFL thickness in the evaluation of glaucoma should always be interpreted with reference to the refractive status, so as not to cause misdiagnosis of glaucoma. The highest diagnosis efficiency position of glaucoma is infratemporal(7:00～8:00 o'clock)and superior temporal(10:00～11:00 o'clock), which is not thinner in juvenile myopia, if these positions become thinner, it may be the possibility of glaucoma.