方法：本研究采用临床对照研究。将行白内障超声乳化联合人工晶状体植入术的糖尿病患者分成两组，治疗组(34眼)术后1d始接受口服芪明颗粒4.5g，每日 3 次和维生素C片0.1g，每日3次治疗； 对照组(42眼)接受维生素C片0.1g，每日3次。6mo后使用相干断层扫描仪(optical coherence tomography，OCT)检测黄斑囊样水肿的发病率和所有患者黄斑中心区视网膜厚度。

结果：OCT检查发现，治疗组黄斑囊样水肿2眼(6%)，对照组黄斑囊样水肿6眼(14%)，差异无统计学意义(P=0.285)； 治疗组黄斑中心凹视网膜厚度(211.76±41.21μm)显著低于对照组(278.36±48.94μm)(P<0.01)。

结论：芪明颗粒有助于减少糖尿病患者白内障术后黄斑视网膜厚度的增加。

METHODS:In this was a prospective clinical comparison study, 57 diabetic patients(76 eyes)who underwent phacoemulsification were recruited and divided into two groups: treatment group(34 eyes)and control group(42 eyes). All the patients in treatment group were given oral administration Qi ming granule(4.5g, tid)and vitamin C(0.1g, tid)for 6mo postoperatively, while vitamin C(0.1g, tid)for the controls. General clinical examinations, including blood glucose and glycated hemoglobin, as well as comprehensive standardized ophthalmic examinations were performed. Optical coherence tomography(OCT)were used to detect macular edema incidence and measure central field retinal thickness.

RESULTS: No significant difference was found in the levels of blood glucose,glycated hemoglobin, course of disease, and macular thickness between the two groups during the initial visits. At the 6^th month, 2 eyes(6%)eyes had clinically apparent macular edema in treatment group, while 6(14%)eyes had clinically apparent macular edema in control group(P=0.285). The central subfield retinal thickness values were significantly lower in the treatment group(211.76±41.21μm)than those in control group(278.36±48.94μm)(P<0.01).

CONCLUSION:Qi ming granule can significantly reduce the incidences of macular edema and suppresses increasing retinal thickening after phacoemulsification in patients with diabetes mellitus.