方法：随机选取干眼患者50例。随机选取一眼滴用表面麻醉剂纳入试验组，另一眼用9g/L生理盐水点眼纳入对照组，点药15min后通过眼前节相干光学断层扫描仪(anterior segment optical coherence tomography，AS-OCT)记录并比较两组的泪河高度(tear meniscus height，TMH)、泪河深度(tear meniscus depth，TMD)以及泪河横截面面积(tear meniscus area，TMA)。

结果：表面麻醉剂使用后TMH为0.173±0.040mm，TMD为0.166±0.019mm，TMA为0.049±0.013mm²，与点药前相比，差异均有统计学意义(t_TMH =2.78，P<0.01； t_TMD=2.31，P<0.01； t_TMA=2.69，P<0.01)，点药后两组相比，差异均有统计学意义(t_TMH =5.87，P<0.01； t_TMD=2.04，P<0.05； t_TMA=4.63，P<0.01)。

结论：表面麻醉剂减少干眼患者泪液分泌量，临床工作中应加强预防和干预。

METHODS:Fifty cases with dry eyes were chosen in this clinical trial. They were randomly divided into two groups, one group as the experimental group, using topical instillation; another group as the control group, with 9g/L saline instillation. After 15min, anterior segment optical coherence tomography(AS-OCT)was used to measure tear meniscus height(TMH), tear meniscus depth(TMD)and tear meniscus area(TMA)before and after treated with topical anesthetics eye drops, and the changes were compared.

RESULTS:After treated with topical anesthetics eye drops, the value of TMH was 0.173±0.040mm; TMD was 0.166±0.019mm; TMA was 0.049±0.013mm².They were significant different from the values before treated with topical anesthetics(t_TMH=2.78, P<0.01; t_TMD=2.31, P<0.01; t_TMA=2.69, P<0.01). After treated with topical anesthetics eye drops and saline instillation, the value of TMH,TMD,TMA were different between two groups(t_TMH =5.87, P<0.01; t_TMD=2.04, P<0.05; t_TMA=4.63, P<0.01).

CONCLUSION:Topical anesthetics can effectively relieve the tear meniscus in patients with dry eyes,which need to arouse awareness in clinical work.