方法：从本院2007-01/2009-12收治的行LASIK手术治疗的近视患者当中选取90例180眼为研究对象，按照切削方式的不同按自愿非随机选择原则分为3组：非球面切削组、波前引导切削组和常规切削组； 每组均包括低度近视(屈光度≤-3.00D)、中度近视(-3.25 ～-6.00D)、高度近视(-6.25～-9.00D)各10例20眼。对比分析术后3组患者的裸眼视力、角膜 Q 值、高阶像差(RMS值)等视觉质量参数以及患者视觉满意度。

结果：不同激光切削方式术后的裸眼视力均达到1.0以上，组间差异均无显著性(P=0.26)； 术后角膜Q值均有所增加，但非球面切削组明显小于常规切削组和波前引导切削组(P<0.05)； 术后各组的高阶像差RMS值均较术前增加，非球面切削组和波前引导切削组明显小于常规切削组(P<0.05)，非球面切削组和波前引导切削组两组间差异无显著性意义； 术后3组患者均感到满意，非球面切削组视觉非常满意度要高于另外两组，但差异不具有统计学意义(P=0.57)。

结论：常规切削、非球面切削、波前引导切削LASIK治疗近视均能够取得较好的视觉质量，其中非球面切削的临床应用效果更好。

METHODS: From our hospital between January 2007 and December 2009, the independent line during LASIK surgery in 90 patients(180 eyes)with myopia as the research subjects. According to the different way of cutting and the voluntary principle of nonrandom selection, the patients were divided into three groups: aspheric cutting group, wavefront guided cutting group and conventional cutting group. Each group included low myopia(diopter: ≤-3.00D), moderate myopia(diopter: -3.25～-6.00D), high myopia(diopter: -6.25～-9.00D)and 10 cases(20 eyes). Postoperative uncorrected visual acuity, corneal Q value, higher-order aberrations(RMS value)and visual quality parameters, such as patients with visual satisfaction were compared and analyzed among three groups.

RESULTS: Postoperative uncorrected visual acuity was 1.0 or more after surgery with three different laser cutting modes, without significant difference between groups(P=0.26). Postoperative corneal Q value increased, it was smaller in aspheric cutting group than other two groups, with a statistically significant difference(P<0.05). The high-order aberration RMS values of three groups was increased compared with preoperative, it was significantly smaller in aspheric cutting group and wavefront guided cutting group than that in conventional cutting group(P<0.05). There was no significant difference between aspheric cutting group and wavefront guided cutting group(P>0.05). All patients were satisfied after surgery, it was was obviously higher in aspheric cutting group than other two groups, with no statistical significance(P=0.57)

CONCLUSION:Conventional, aspheric and wavefront guided cutting in LASIK for the treatment of myopia are able to obtain a better visual quality and clinical application, while the effect of aspheric cutting is better.