目的：检测原发性急性闭角型青光眼与对照组围手术期外周血IL-2和IL-6水平差异，探讨细胞因子水平与原发性急性闭角型青光眼视神经损伤的相关性。

方法：收集2013-05/2014-10我院眼科住院原发性急性闭角型青光眼患者作为病例组，按视神经损伤程度分为轻、中、重3组。同期住院白内障患者作为对照组，采用双抗体夹心酶联免疫吸附法测定研究对象外周血IL-2、IL-6浓度，分别比较病例组、对照组患者间以及不同视野损伤程度三组患者间细胞因子质量浓度的差异，分析原发性急性闭角型青光眼患者机体中细胞因子水平与视神经损伤程度的相关性。

结果：病例组血清中IL-2、IL-6浓度显著低于对照组(P<0.05)。重度视神经损伤组 IL-2、IL-6浓度显著低于轻度视神经损伤组(P<0.05)。视野损伤程度不同的三组IL-2、IL-6水平与视神经损伤严重程度进行多重线性回归分析，IL-2水平差异有统计学意义(P<0.05)。

结论：原发性急性闭角型青光眼患者机体内IL-2、IL-6水平降低。原发性急性闭角型青光眼患者IL-2水平可能与视神经损伤有关。

AIM:To compare the levels of IL-2 and IL-6 between primary acute angle-closure glaucoma and normal controls at perioperative. To discuss the correlations between cytokine levels and optic nerve damage of primary acute angle-closure glaucoma.

METHODS: Hospitalized patients with primary acute angle-closure glaucoma in the Department of Ophthalmology of Yongchuan Hospital of Chongqing Medical University from May, 2013 to October, 2014 were collected as the case group(Group A), Group A was divided into three subgroups of minor, medium and severe(a, b and c)according to the degree of optic nerve injury. The patients with cataract hospitalized within the same period were selected as the control group(Group B). The concentrations of IL-2 and IL-6 in the peripheral blood of research objects were determined with the double-antibody sandwich enzyme-linked immunosorbent assay(ELISA). The differences in the mass concentration of cytokines between the two groups of A and B and the three subgroups of a, b and c were compared, and the correlation between the level of cytokines in the bodies of patients with primary acute angle-closure glaucoma and the degree of optic nerve injury was analyzed.

RESULTS: Concentrations of IL-2 and IL-6 in experimental group were significantly lower than those in the control group(P<0.05). Concentrations of IL-2 and IL-6 in glaucoma patients severe injury of optic nerve were significantly lower than those in mild injury of optic nerve( P<0.05). To discuss the correlations between cytokine levels and optic nerve damage in subgroups a, b, and c, mult-variable linear return analysis was used, the difference on IL-2 level had statistical significance(P<0.05).

CONCLUSION: In primary acute angle-closure glaucoma patient, levels of IL-2 and IL- 6 are lower than the normal. IL-2 may be associated with glaucomatous optic neuropathy.

重庆市卫生局面上项目(No.2011-1-088); 重庆市教委科学技术研究项目(No.KJ120317)