方法：制备新西兰兔干眼动物模型，使用1g/L玻璃酸钠和3g/L玻璃酸钠滴滴液治疗，分别作为低浓度治疗组(B组)和高浓度治疗组(C组)，生理盐水治疗作为对照组(A组)。分别观察角膜荧光染色、泪液分泌试验、结膜杯状细胞及黏蛋白表达和组织学变化。

结果：治疗后D7和D14时，B组及C组角膜荧光染色评分低于A组(P<0.05)，泪液分泌、杯状细胞密度及黏蛋白含量高于A组(P<0.05)。C组角膜泪液分泌和杯状细胞密度高于B组(P<0.05)。与B组和C组相比较，A组角膜及结膜上皮细胞层变薄，角膜及结膜基质未见明显异常。

结论：玻璃酸钠能够改善干眼眼表损害，且高浓度治疗效果优于低浓度。

METHODS: New Zealand rabbits with dry eye was prepared and treated with 0.1% and 0.3% sodium hyaluronate drops fluid respectively, which were regarded as low concentration treatment group(group B)and high concentration treatment group(group C)respectively. However, the rabbits treated with saline were regarded as control group(group A). And then, corneal fluorescein staining, Schirmer test, conjunctival goblet cells, mucin expression and histological changes were observed.

RESULTS: On D7 and D14 after treatment, corneal fluorescein staining scores were lower in group B and group C than that in group A(P<0.05). However, Schirmer test, goblet cell density and mucin content were higher in group B and group C than those in A group(P <0.05). Tear secretion and goblet cell density were higher in Group C than those in group B(P<0.05). Compared with group B and group C, the thicknesses of corneal and conjunctival epithelial cell layer were thinner in group A. There were not obvious abnormalities in corneal and conjunctival stroma in each group.

CONCLUSION: The sodium hyaluronate can improve ocular surface damage of dry eye in New Zealand rabbits. The high concentration of sodium hyaluronate has better effect than low concentration.