目的：分析白内障围手术期使用溴芬酸钠眼液的术后黄斑中心凹厚度变化及黄斑水肿的发生率，评估此种非类固醇抗炎药预防白内障术后黄斑水肿的应用价值。

方法：对我院同一位医生所行白内障超声乳化联合人工晶状体植入的患者进行临床资料回顾性分析。溴芬酸钠组26眼，术前3d及术后2wk应用溴芬酸钠眼液，每日2次，术后2wk应用妥布霉素地塞米松眼液，每日4次； 对照组26眼仅术后点用妥布霉素地塞米松眼液。术前及术后1mo分析黄斑中心凹厚度及黄斑水肿发生率。

结果：手术前后溴芬酸钠组的黄斑中心凹厚度分别为221.077±22.194、221.692±29.685μm，无统计学差异(P>0.05)； 对照组的黄斑中心凹厚度分别为222.769±21.562、249.538±63.153μm，具有统计学差异(P<0.05)； 术后两组黄斑中心凹厚度具有统计学差异(P<0.05)； 但两组的黄斑水肿发生率分别是0和3.85%，两者比较差异无统计学意义(P>0.05)。

结论：白内障围手术期使用溴芬酸钠眼液有可能减少术后黄斑中心凹的增厚，预防黄斑水肿的发生。

AIM: To observe the change of macular fovea thickness and the incidence of cystoid macular edema(CME)after cataract surgery by using bromfenac sodium eyedrops in perioperative period, to access the applying value of this kind of non-steroidal anti-inflammatory drugs(NSAIDs)on preventing postoperative CME.

METHODS: The clinical data of patients received phacomulsification and intraocular lens(IOL)implantation surgeries by the same operator were retrospective analyzed. Twenty patients(26 eyes)in trial group received the treatment of topical bromfenac sodium(twice per day for 3d preoperatively and twice per day for 2wk postoperatively)combined with tobramycin and dexamethasone(four times per day for 2wk postoperatively). Nineteen patients(26 eyes)in the control group only used tobramycin and dexamethasone eyedrops. The changes of macular fovea thickness and the incidence of CME preoperative and 1mo postoperative were analyzed.

RESULTS: The mean macular fovea thickness of two groups improved from 221.077±22.194μm and 222.769±21.562μm preoperatively to 221.692±29.685μm and 249.538±63.153μm postoperatively respectively. There was no statistical difference in the trial group between preoperative and postoperative(P>0.05), however, there were statistical differences compare that of preoperative and postoperative in the control group and postoperative between two groups(P<0.05). The incidence of CME was 0 and 3.85% in two groups with no statistical significance(P>0.05).

CONCLUSION: The topical use of bromfenac sodium eyedrops in perioperative period possibly can prevent the increase of macular fovea thickness and the occurrence of CME after cataract surgery.