方法：回顾性分析31例58眼患者药物毒性角膜病变病因，对使用药物的种类、频率、周期，以及角膜病变的临床表现作分类统计，对明确诊断者，停用原有滴眼药物，使用低角膜毒性药物及无防腐剂的滴眼液，观察治疗效果。

结果：数据表明，药物毒性角膜病变有点状、假性树枝状、弥漫性角膜炎和角膜基质浸润。患者均有多种药物的频繁、长期使用史。患者58眼的平均用药种类为3.60±0.74，平均用药频率12.08±2.12次/d，平均用药时间25.58±11.41d。治疗时间平均为29.5d。治愈54眼，治愈率为93.10%，好转4眼，占6.90%。

结论：药物毒性角膜病变与药物的种类、用药物的频率、使用的时间周期有明显的关系，明确诊断、规范医疗用药以减少和避免药物毒性角膜病变的发生是至关重要的。

METHODS: A retrospective analysis on 58 eyes of 31 patients with drug toxic keratopathy was processed. The types, the frequencies and application periods, and the clinical manifestations of keratopathy were categorized. For those diagnosed, all drops were stopped, instead, low-cornea-toxic and preservative-free drops were used. The treatment results were followed.

RESULTS: Data indicated that drug toxic keratopathy included punctate, false dendritic, diffuse keratitis and stromal infiltration. All patients presented the history of the frequent and long-term using of multiple eye drops. For all 58 eyes, the average drops type was 3.60±0.74, the average frequency and period of drop application was 12.08±2.12 times per day, and 25.58±11.41d, and the average treatment period was 29.5d. After treatment, 54 eyes(93.10%)were recovered and 4 eyes(6.90%)improved.

CONCLUSION: Drug toxic keratopathy has close relationship with the variety drug types, frequency and period of drops application. Correct diagnoses and standardized drug treatment are essential to reduce or prevent the occurrence of drug toxic keratopathy.