目的：通过对术后不同时期晶状体内总超氧化物歧化酶(T-superoxide dismatase，T-SOD)及丙二醛(malondialdehyde，MDA)含量的检测，以探讨兔眼玻璃体切除联合非膨胀浓度全氟丙烷(C₃F₈)填充术后早期晶状体的损伤改变是否与氧化损伤有关。

方法：健康新西兰白兔45只分为三组：正常组、对照组和实验组。对照组行单纯玻璃体切除联合平衡盐溶液(BSS)填充术； 实验组行玻璃体切除联合非膨胀浓度C₃F₈填充术。在术后1、3、8、35、45d分别将三组兔眼晶状体取出制成组织匀浆，采用分光光度法分别检测T-SOD和MDA的含量。

结果：T-SOD活力：正常组最高，实验组最低，三组不同时期两两相互比较均有显著统计学差异(P<0.01)。MDA含量：正常组最低，实验组最高，三组不同时期两两相互比较除术后第1d实验组与对照组比较无显著统计学差异外，其余各组两两相互比较均有显著统计学差异(P<0.01)。

结论：兔眼玻璃体切除联合非膨胀浓度C₃F₈气体填充术后早期晶状体混浊可能与氧化损伤有关。

AIM:To study the relationship between oxidative damage and the early pathological changes in rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas, by detecting T-SOD activity and MDA content at different stages after the operation.

METHODS:Fourty five healthy new zealand rabbits were divided randomly to three groups:normal group, control group and experimental group. The control group was just performed vitrectomy with BSS; the experimental group was performed vitrectomy combined with nonexpansile perfluoropropane gas. The lens were made into tissue homogenates to detect T-SOD activity and MDA content by using spectrophotometry on the 1st,3th,8th,35th and 45th day after the operation.

RESULTS:T-SOD activity: that in normal group was the hightest, that in experimental group was the lowest, and there was significant difference(P<0.01)among three groups in every periods after operation. MDA content: that in normal group was the lowest, that in experimental group was the hightest, and there was significant difference(P<0.01)among three groups after the operation except the 1st day.

CONCLUSION:Oxidative damage mechanism may be involved in the early damge of rabbit lens after vitrectomy combined with nonexpansile perfluoropropane gas.