方法：采用自身对照研究，收集2013-03-01/2014-05-30首次在我院配戴夜戴型角膜塑形镜的青少年近视患者84例156眼，其中男40例，女44例，平均年龄12.60±2.03岁，平均等效球镜度(SE)为-3.65±0.79D。将所有患者按屈光度不同分为A组(-0.75～-2.00D)，B组(-2.25～-4.00D)，C组(-4.25～-6.00D)。所有患者每晚配戴8h以上，分别于配戴前及配戴后1、6、12mo接受裸眼视力(UCVA)、主觉验光、矫正视力(BCVA)、对比敏感度(CSF)检查，采用SPSS17.0统计学软件对相关数据进行重复测试单因素方差分析。

结果：视力和等效球镜比较：A、B、C三组配戴角膜塑形镜后1、6、12mo裸眼视力明显提高，SE下降，配戴前与配戴后比较差异均具有统计学异常(P<0.05)，而配戴后1、6mo与12mo比较差异无统计学意义(P>0.05)。配戴前后矫正视力比较差异无统计学意义(P>0.05)。对比敏感度比较：A、B、C三组配戴角膜塑形镜后1、6、12mo对比敏感度各空间频率与戴镜前相比：在低空间频率(3c/d(周弧度))和高空间频率(18c/d)基本无变化，在中空间频率(6、12c/d)A、B组均表现为较戴镜前略有增加，而C组表现为较戴镜前略有降低，但戴镜前后比较差异均无统计学意义(P>0.05)。

结论：夜戴型角膜塑形镜配戴能提高裸眼视力，同时对整体视觉质量并无明显影响，值得临床推广应用。

METHODS:A self-controlled study was used. Eighty four young myopic subjects(156 eyes)aged 12.60±2.03 years in which there were forty males and forty-four females with spherical equivalent(SE)-3.65±0.79D were recruited in the study from March 1^st 2013 to May 30^th 2015. Based on diopters, the subjects were divided into group A(-0.75～-2.00D), group B(-2.25～-4.00D)and group C(-4.25～-6.00D). All the lenses were worn every night over 8 hours. Uncorrected visual acuity(UCVA),subjective refraction,best corrected visual acuity(BCVA), contrast sensitivity function were examined before,1,6,12mo after the initiation of orthokeratology. The database was analyzed by SPSS17.0 using one-way ANOVA.

RESULT:1)Comparison between risual acuity and SE: The UCVA improved significantly and SE decreased after wearing orthokeratology lens 1,6,12mo in 3 groups, showing significant decline in comparison with that before orthokeratology(P<0.05). There was no significant change among 1,6,12mo after wearing orthokeratology(P>0.05). There was no significant change in BCVA(P>0.05). 2)Comparison on contrast sensitivity function: Contrast sensitivity function at all spatial frequencies in 3 groups 1,6,12mo after wearing lenses compared with those before wearing: There was no change before and after wearing at the low spatial frequency(3c/d)and the high spatial frequency(18c/d), but slight increases in group A and group B in the spatial frequency(6c/d, 12c/d)after wearing lenses. There were slight decreases in group C at all spatial frequencies after wearing.But there was no statistical significance between before and after wearing in all three groups(P>0.05).

CONCLUSION:Overnight orthokeratology can improve UCVA and has no obvious effect on the overall visual quality. It deserves to be applied and spreaded in clinical practice.