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[摘要]
目的：运用血氧水平依赖性功能核磁共振成像技术(BOLD-functional magnetic resonance imaging，BOLD-fMRI)阶段性评价屈光参差性弱视儿童在规范弱视训练后视皮质相关功能区激活情况。
方法：收集先期研究及后续收集屈光参差性弱视儿童共13例进行任务态组块模式(Blocks)的功能磁共振(fMRI)研究，采用前后对照t检验对规范弱视治疗18mo和24mo及终止治疗6mo后的脑功能激活数据进行分析。图像处理平台为Matlab 7.12.0.635的SPM8软件。
结果：各阶段功能区激活主要集中在左枕叶(Brodmann 18区)、枕中回(Brodmann 19区)、边缘叶(Brodmann 19区)、双侧顶上小叶(Brodmann 7区)、右枕叶舌回(Brodmann 17区)，弱视治疗24mo激活范围无明显扩大，差异无统计学意义(mean T=1.014，P>0.01)，终止治疗6mo后激活范围差异无统计学意义(mean T=0.9793，P>0.01)。
结论：屈光参差性弱视治疗2a后视中枢基本稳定，持续弱视治疗对于视中枢功能重建无显著作用。
[Key word]
[Abstract]
AIM: To periodically evaluate the anisometropia amblyopic children's activation of the visual cortex function after training normatively by blood oxygen level dependent-functional magnetic resonance imaging(BOLD-fMRI).
METHODS:Thirteen children with anisometropia amblyopic from advanced research and subsequent research were collected. Self-controlled study before and after treatment and blocks-designed fMRI was performed. fMRI data were processed by using SPM8 which based on the Matlab 7.12.0.635. T test was used to compare and analyze the difference of the brain activation data before and 18, 24mo after amblyopia treatment and 6mo after stopped treatment.
RESULTS: The activation ranges in all these periods are Brodmann 7, 17, 18, and 19; After normalized treatment 24mo(mean T=1.014; P>0.01). and after stopped treatment 6mo(mean T=0.9793, P>0.01). The increasing of the activation ranges in visual cortex was unconspicuous.
CONCLUSION: Visual cortex is basically stable after 2a of anisometropic amblyopia treatment, and continuous treatment for amblyopia has no significant effect on visual cortex function reconstruction.
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