方法：选取2011-06/2014-12 DR患者60例为研究对象。 根据DR国际分期无明显视网膜病变的28例，轻、中、重非增生性视网膜病变22例，增生性糖尿病视网膜病变10例。选择60例糖尿病无视网膜病变患者为疾病对照组(NDR组)； 选择60例健康者为健康对照组。检测受试者胱抑素C、甘油三酯及总胆固醇水平。

结果：DR组胱抑素 C、甘油三酯及总胆固醇水平高于NDR组和健康对照组，而NDR组高于健康对照组，差异有统计学意义(P<0.05)； 随着DR病变程度的加重，胱抑素 C水平呈增加趋势，差异有统计学意义(P<0.05)； 胱抑素C与病程、血脂水平呈正相关(P<0.05)。

结论：DR患者存在胱抑素C水平异常变化，且随着DR的进展，胱抑素C水平呈不断升高趋势。DR患者胱抑素C水平的变化与血脂异常相关。

METHODS:Sixty patients with DR from June 2011 to December 2014 were selected. According to international criteria, in the patients with DR, there were 28 cases without remarkable DR, 22 cases with mild, middle and sever nonproliferative diabetic retinopathy(NPDR), 10 cases with proliferative diabetic retinopathy(PDR).Sixty diabetic patients without DR were selected as NDR group. Sixty healthy people were selected as control group. Cys C, triglyceride(TG)and total cholesterol(TC)were detected.

RESULTS:In DR group, Cys C, TG and TC levels were higher than those in the NDR group and the control group, while in NDR group Cys C, TG and TC levels were higher than thoes in the control group, and the difference was statistically significant(P< 0.05). As DR aggravating, Cys C increased, and the difference was statistically significant(P<0.05). Cys C were positively correlated with the duration and blood lipid level(P<0.05).

CONCLUSION:Cys C changes abnormally in patients with DR, and with the progress of DR, Cys C trends to increase. The abnormal changes in DR patients positively associated with dyslipidemia.