方法：选择行激光矫正的高度近视患者120例240眼。随机分TransPRK术组60例120眼，LASEK术组60例120眼。观察术后1wk眼部刺激症状、术后2wk视力、术后3mo haze的发病率、术后1a屈光度等。

结果：两种方法均取得良好的手术效果。术后第1d TransPRK组无刺激症状者：86眼(71.7%)，视物清楚，睁眼来医院复查。LASEK组术后81眼(67.5%)无刺激症状； 术后2wk视力与术前矫正视力比较，TransPRK组109眼(90.8%)，LASEK组87眼(72.5%)； 术后3mo haze的发病率，TransPRK组0级113眼，LASEK组0级109眼。

结论：TransPRK组刺激症状明显轻于LASEK组，TransPRK组比LASEK组术后视力恢复快； TransPRK组比LASEK组术后haze的发病率低，以上均有统计学差异(P<0.01)； 术后两组1、3、6、12mo两组视力、屈光状态、视觉质量均无统计学意义(P>0.05)。两种手术方式矫正高度近视疗效无明显差异，均具有较好的安全性、有效性及可预测性。

METHODS:This study included 120 patients(240 eyes)with high myopic, which were divided into TransPRK(60 patients with 120 eyes)group and LASEK group(60 patients with 120 eyes)randomly. Recovery status, visual acuity, haze condition and refractions of the two groups were compared respectively at 1, 2wk, 3mo and 1a.

RESULTS:The clinical results were very good for both groups. But at 1d post-operative, 86 eyes(71.7%)in TransPRK group felt no discomfort and had clear vision while there were 81 eyes(67.5%)in LASEK group having the same condition. One hundred and nine eyes(90.8%)had better UCVA than their BCVA pre-operative in TransPRK group compared to 87 eyes(72.5%)in LASEK group at 2wk post-operative. At 3mo post-operative, 113 eyes in TransPRK group had no haze(grade 0), compared to the 109 eyes in LASEK group.

CONCLUSION:TransPRK had faster recovery of visual acuity and less discomfort than LASEK. And rate of haze was statistically lower in TransPRK group(P<0.01). However, the visual acuity, refractions and vision quality at 1, 3, 6mo and 1a were not statistically different(P>0.05). Finally, there was no significant difference on the efficiency, safety and predictability of high myopia treatments between the two methods.