方法：对确诊为药物源性角结膜炎的18例患者的病历资料进行回顾性分析，观察药物源性角结膜炎的原发疾病、用药种类、药物使用频率、临床特征、治疗方法、上皮愈合时间和患者的非矫正视力(UCVA)。使用SPSS 18.0统计学软件进行分析，以P<0.05为差异有统计学意义。

结果：药物源性角结膜炎的常见原发疾病包括青光眼(6例)、单纯疱疹病毒性角膜炎(6例，其中2例为白内障术后)、带状疱疹病毒性角膜炎(1例)、角膜异物剔除后角膜炎(1例)和无明确病因角膜炎/角膜溃疡(4例)。患者的用药种类为3.3±1.5种，用药频率是9±3.9次/d。16例患者出现角膜病变，而仅有3例患者出现结膜病变(其中1例患者同时出现角膜和结膜病变)。患者的治疗方案包括停用原有药物，局部使用不含防腐剂的人工泪液或自体血清，以及低剂量类固醇眼药水。在治疗周期7±2.8d后，患者症状开始缓解。患者上皮愈合周期是21±8.8d。治疗前后患者的UCVA分别是0.15±0.13和0.43±0.27(P=0.003)。

结论：病毒性角膜炎和青光眼是药物源性角结膜炎的最常见原发疾病。

METHODS: The clinical records of 18 patients with a confirmed diagnosis of drug-induced keratoconjunctivitis were retrospectively reviewed. Primary diseases, categories of induced-drugs, numbers of daily drops, characteristics of keratoconjunctivitis, treatment, epithelization period, and un-corrected visual acuity(UCVA)were studied. Data were analyzed by SPSS 18.0. P<0.05 were considered statistically significant.

RESULTS: Primary diseases included glaucoma(n=6), herpes simplex keratitis(n=6; two patients were post-surgery of cataract), herpes zoster keratitis(n=1), keratitis after corneal foreign body taken(n=1)and keratitis/corneal ulcer with unknown etiology(n=4). Mean number of drugs was 3.3±1.5 and the frequency was 9±3.9 times a day. Keratopathy was found in 16 cases, while conjunctival changes were found only in 3 cases(One patient got corneal and conjunctival changes simultaneously). Withdrawing the drugs, preservative-free lubricants or autologous serum, and topical low dose steroid drops were used for treatment. After a mean period of 7±2.8d, symptoms began to relieve. The mean epithelization period was 21±8.8d. Mean pretreatment and post-treatment UCVA was 0.15±0.13 and 0.43±0.27, respectively(P=0.003).

CONCLUSION: Viral keratitis and glaucoma are the most often events of drug-induced keratoconjunctivitis.