[关键词]
[摘要]
年龄相关性黄斑变性(age-related macular degeneration，AMD)是导致老年人不可逆性失明的最常见原因之一。活性氧引起的氧化应激作为年龄相关性疾病的危险因素，证实与AMD的发病相关。锰超氧化物歧化酶(manganese superoxide dismutase，MnSOD)，作为机体一线抗氧化酶在视网膜中表达，已经在动物水平、细胞水平、患者水平三个层面证实与AMD发病相关。本文将对近年MnSOD与AMD相关性的研究进展作出综述。
[Key word]
[Abstract]
Age-related macular degeneration(AMD)is one of the leading causes of senile irreversible blindness. The oxidative stress caused by reactive oxygen species(ROS), as a risk factor of AMD, plays a role in the pathogenesis of AMD. Manganese superoxide dismutase(MnSOD), as one of the first line antioxidant enzymes, could be expressed in retina cells.It has been demonstrated that MnSOD is correlated with AMD and has been confirmed in animals, cellular level, and patients. This article reviewed the recent literatures on the research and progress of the relation between MnSOD and AMD.
[中图分类号]
[基金项目]
国家自然科学基金面上项目(No.81470648)
