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[摘要]
目的：比较国产和进口前列素类药物治疗首次诊断的开角型青光眼患者的短期疗效。
方法：采用前瞻性阳性药物对照研究338例首次诊断的原发性开角型青光眼，依据患者意愿，分为试验组181例，对照组157例，试验组接受国产0.05g/L拉坦前列素3mo治疗，对照组接受进口0.04g/L曲伏前列素3mo治疗，所有患者均每天21：00给药一次，疗程3mo。分别于治疗前、治疗后1、2、3mo测定每组患者的眼压水平。
结果：试验组用药后1、2、3mo的眼压分别是21.84±4.63、19.53±4.04、18.15±3.35mmHg(1mmHg=0.133kPa)，相比于治疗前的基础眼压28.32±5.72mmHg明显下降，各时间点眼压值的总体差异有统计学意义(F=370.019，P=0.000)，其中治疗后各时间点的眼压值均明显低于治疗前，差异均有统计学意义(P<0.01)； 对照组用药后1、2、3mo的眼压分别是21.91±5.22、19.80±4.26、18.76±3.46mmHg，相比于治疗前的基础眼压27.6±5.14mmHg明显下降，各时间点眼压值的总体差异有统计学意义(F=306.052，P=0.000)，其中治疗后各时间点的眼压值均明显低于治疗前，差异均有统计学意义(P<0.01)。此外，两组患者在治疗后1、2、3mo随访时眼压水平的差异没有统计学意义(P=0.144、0.456、0.051)。
结论：国产拉坦前列素滴眼液可有效降低眼压，且价格经济，可作为基层医院原发性开角型青光眼的首选药物。
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[Abstract]
AIM: To compare the short-term efficacy of domestic and imported prostaglandins(PGs)for patients first diagnosed as primary open angle glaucoma.
METHODS: This study was a prospective positive drug control trial and 338 patients diagnosed as primary open angle glaucoma at the first time. According to patients' wills, they were divided into the experiment group(181 cases)and the control group(157 cases). Domestic latanoprost eye drops with 0.05g/L was used for 3mo in the experimental group while imported travoprost eye drops with 0.04g/L was used in the control group for 3mo. All patients were typically treated at 21:00 every day within a 3mo period. Intraocular pressure(IOP)was measured before treatments and post treatments at 1, 2 and 3mo respectively, in each group.
RESULTS: For the experimental group, IOP was 28.32±5.72, 21.84±4.63, 19.53±4.04 and 18.15±3.35mmHg before treatments and post treatments at 1,2 and 3mo respectively, showing a significant difference among various time points(F=370.019,P=0.000),and the IOPs were markedly lower post treatments than those before treatments(all P<0.01). For the control group, IOP was 27.6±5.14, 21.91±5.22,19.80±4.26 and 18.76±3.46mmHg before treatments and post treatments at 1,2 and 3mo respectively, showing a significant difference among various time points(F=306.052,P=0.000),and the IOP were markedly lower post treatments than those before treatments(all P<0.01). The difference of IOP level was not significant at post-treatment 1, 2 and 3mo respectively between two groups(P=0.144,0.456, 0.051).
CONCLUSION: Domestic latanoprost eye drops can reduce IOP effectively, with a suitable price, and it can be used as a first choice for primary open angle glaucoma patients in the basic-level hospitals.
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