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[摘要]
目的:观察角膜缘干细胞移植术治疗翼状胬肉切除联合羊膜移植术后羊膜溶解的临床效果。
方法:翼状胬肉切除术联合羊膜移植术后出现羊膜溶解的患者124例135眼随机分成A、B、C三组,A组36例38眼采取保守治疗,B组42例45眼再次行羊膜移植术,C组46例52眼行自体角膜缘干细胞移植术。术后随访6~18mo比较各组胬肉复发情况。
结果:A组38眼中24眼复发,复发率63.2%。B组45眼中术后7眼胬肉复发,复发率15. 6%。C组52眼2眼复发,复发率3.8%,A组与B组比较,B组与C组比较差异均有统计学意义(P<0.05)。
结论:自体角膜缘干细胞移植术是治疗翼状胬肉切除联合羊膜移植术后羊膜溶解的有效方法。
[Key word]
[Abstract]
AIM: To observe the efficacy of the corneal limbus stem cell transplantation on treating amniotic membrane dissolving after pterygium resection with amniotic membrane transplantation.
METHODS: One hundred and twenty-four patients(135 eyes)with amniotic membrane dissolving after pterygium resection and amniotic membrane transplantation were randomly divided into groups A, B and C. In group A, 36 cases(38 eyes)took the conservative treatment. In group B, 42 cases(45 eyes)accepted amniotic membrane transplantation again. In group C, 46 cases(52 eyes)were performed corneal limbal stem cell transplantation. Postoperative follow-up periods were 6~18mo.
RESULTS:Twenty-four eyes in group A were recurred and the recurrence rate was 63.2%. Seven eyes in group B were recurred and the recurrence rate was 15. 6%. Two eyes in group C were recurred and the recurrence rate was 3.8%. The differences on recurrence rate between group A and group B, between group B and group C were statistically significant(P<0.05).
CONCLUSION: Autologous corneal limbus stem cell transplantation is an effective treatment for amniotic membrane dissolving after pterygium resection with amniotic membrane transplantation.
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