[关键词]
[摘要]
目的：研究近视患者近视发病时间(T)对黄斑区脉络膜厚度(CT)的影响。
方法：采用前瞻性队列研究方法。纳入2014-03/2015-04间在我院屈光手术中心行手术前检查的122例244眼近视患者。其中，男67例，女55例。年龄30～41(平均35.1±4.6)岁。根据发病时间分成3组：A组(T≤5a)、B组(5aF=1.56，P>0.05)、年龄(F=2.13，P>0.05)、最佳矫正视力(F=1.41，P>0.05)、角膜曲率(F=1.65，P>0.05)、眼轴长度(F=1.89，P>0.05)差异均无统计学意义。受检查者黄斑区脉络膜使用频域光相干断层扫描(SD-OCT)的深度增强成像(EDI)技术进行扫描。测量中心凹下CT(SFCT)以及距中心凹1、3mm处上方(S)、下方(I)、颞侧(T)、鼻侧(N)4个方位的CT。各方位点分别标记为S1mm、I1mm、T1mm、N1mm、S3mm、I3mm、T3mm、N3mm。分析三组间脉络膜相同位点CT值的差异。结果：A、B、C组的平均SFCT值分别为238.32±57.95、230.58±67.21、221.63±62.37μm。A、B组间及B、C组间除N3mm外(tA-B=4.34、tB-C=7.61，P<0.05)，其余各位点的CT值差异均无统计学意义(P>0.05)； A、C组间除T3mm外(t=0.76，P>0.05)，其余各位点的CT值差异均有统计学意义(P<0.05)； 三组间两两比较，N3mm的CT值差异均有统计学意义(tA-B=4.31、tB-C=7.59、tA-C=12.18，P<0.05)。
结论：随着近视发病时间的延长，近视患者的脉络膜厚度变薄，鼻侧尤为明显。
[Key word]
[Abstract]
AIM:To investigate the effect of onset time(T)for macula choroidal thickness(CT)in myopia patient.
METHODS:A prospective cohort study was designed.One hundred and twenty-two myopia patients(244 eyes; 67 male and 55 female; aged 30～41 years, mean 35.1±4.6 years old)who received preoperative examinations from March 2014 to April 2015 were recruited in this study. The patients were divided into three groups according to onset time(T):group A(T≤5a), group B(5aF=1.56,P>0.05),age(F=2.13,P>0.05),best corrected visual acuity(BCVA, F=1.41,P>0.05),corneal curvature(F=1.65,P>0.05)and axial length(F=1.89,P>0.05)among the three groups. The choroid in macular region was measured by enhanced depth imaging(EDI)using spectral-domain optical coherence tomography(SD-OCT). This study recorded the CT at subfoveal(SFCT), 1mm at temporal(T1mm), nasal(N1mm), superior(S1mm)and inferior(I1mm)to the fovea and 3mm temporal(T3mm), nasal(N3mm), superior(S3mm)and inferior(I3mm)to the fovea, respectively. The differences of CT at the same position among the three groups were analyzed.RESULTS:The mean SFCT for group A,B,C were 238.32±57.95μm, 230.58±67.21μm, 221.63±62.37μm respectively in this study. The CT was found no significant difference in different locations except N3mm(tA-B=4.34,P<0.05)between group A and B. The CT was found no significant difference in different locations except N3mm(tB-C=7.61,P<0.05)between group B and C. The CT was found significant difference in different locations, except T3mm(t=0.76,P>0.05)between group A and C. Significant difference was found at N3mm(tA-B=4.31,t B-C=7.59,tA-C=12.18; P<0.05)among the three groups.
CONCLUSION:The choroidal thickness decreases as the myopia onset time is earlier, especially at nasal.
[中图分类号]
[基金项目]
爱尔眼科医院集团2014年度科研项目(No.AF143D09)
