目的：观察睑板腺功能障碍患者术前行睑板腺处理对飞秒激光制瓣膜的准分子激光角膜原位磨镶术(IntraLase-LASIK)术后眼表炎症反应和泪膜状态的改变。

方法：选取2014-03/09来我院屈光门诊就诊拟行IntraLase-LASIK术并有不同程度睑板腺功能障碍的患者35例70眼。随机数字法将患者分为两组：观察组17例34眼术前给予睑板腺的特殊处理，对照组18例36眼术前不进行睑板腺处理，两组其余操作相同。观察IntraLase-LASIK术后1d和1wk眼球结膜充血、畏光、干涩感评分及泪膜破裂时间(tear break-up time，BUT)的变化。

结果：术后1d和1wk观察组的球结膜充血、畏光、干涩感评分及BUT均低于对照组(P<0.05)。

结论：睑板腺功能障碍的患者术前睑板腺处理可以减轻术后的眼表刺激症状，对泪膜起到一定的稳定作用，提高患者术后的满意度。

AIM:To observe the changes of ocular surface inflammation and tear film state before and after the operation after preoperative targeted therapy for Meibomian gland in the patients scheduled for IntraLase-LASIK with Meibomian gland dysfunction(MGD).

METHODS: Thirty-five patients(70 eyes)scheduled for IntraLase-LASIK with different degrees of MGD from March to September 2014 were enrolled in this study. All patients were randomly divided into 2 groups, 17 patients(34 eyes)in the observation group accepted preoperative targeted therapy for Meibomian gland; 18 patients(36 eyes)in the control group did not give the treatment for Meibomian gland, the rest treatments were the same. The change of conjunctival congestion, photophobia, dry symptom score and tear break-up time(BUT)were observed at 1d and 1wk after IntraLase-LASIK.

RESULTS: At 1d and 1wk postoperatively, the scores of conjunctival congestion, photophobia, dry symptom and BUT of the observation group were all lower than those of the control group, and the differences were significant(P<0.05).

CONCLUSION: For the patients scheduled for IntraLase-LASIK with MGD, preoperative targeted therapy for Meibomian gland can reduce the postoperative symptoms of ocular surface irritation, stabilize the tear film, improve the postoperative effect and improve the comfort of patients.