方法：选取2012-09/2013-09急性闭角型青光眼小梁切除术后的患者65例65眼，A组按青光眼临床常规治疗，B组在常规治疗的同时应用丹参多酚酸盐200mg静脉滴注，连续2wk。观察两组术前、术后1wk，3mo的眼压、视网膜神经纤维层(RNFL)厚度的变化情况。

结果：两组术后1wk，3mo的眼压均较术前明显下降， 两组之间无统计学差异。A组术后1wk视乳头颞、上、鼻、下方的RNFL厚度较术前减小，但无统计学意义； 术后3mo颞、上、鼻、下方的RNFL较术前及术后1wk明显减小。B组术后1wk视乳头颞、上、鼻、下方的RNFL较术前减小，但颞、鼻侧无统计学意义； 术后3mo颞、上、鼻、下方的RNFL厚度较术前及术后1wk减小，但较术后1wk时无统计学意义。两组比较，术后1wk，B组上、下方RNFL厚度明显小于A组； 术后3mo，颞、上、下方RNFL厚度明显大于A组。

结论：丹参多酚酸盐能够减轻急性闭角型青光眼发作后RNFL的水肿，延缓RNFL变薄。

METHODS:In the research,We studied 65 patients(65 eyes)with acute angle-closure glaucoma who were selected from September 2012 to September 2013 and treated with trabeculectomy. During the 2wk treatment, postoperatively group A were given conventional therapy according to clinical pathway of glaucoma treatment. Besides these treatment, group B were treated with salvianolate 200mg intravenously per day. The changes of the intraocular pressure(IOP)and retinal nerve fiber layer(RNFL)thickness in the two groups were observed and analyzed statistically before surgery, at 1wk and 3mo after surgery.

RESULTS:The IOPs of the two groups at 1wk and 3mo after operation were lower than that before operation but the difference between the two groups was not significant(P>0.05). In group A, the RNFL thickness at 1wk after surgery was less than that before operation at temporal, superior, nasal and inferior(P>0.05). The RNFL thickness at 3mo after surgery was significantly less than those before operation and at 1wk after surgery at temporal, superior, nasal and inferior. In group B, the RNFL thickness at 1wk after surgery were less than that before operation, but the those at nasal and temporal were without statistical significance. The RNFL thickness at 3mo after surgery was less than that before operation(P<0.05)and that at 1wk after surgery(P>0.05). The superior and inferior RNFL thickness of group B were less than those of group A at 1wk after surgery, and the temporal, superior and inferior RNFL thickness in group B were higher than those in group A at 3mo after surgery.

CONCLUSION:Salvianolate can reduce optic RNFL edema and delay its thinning after glaucoma attack.