方法：选取原发性闭角型青光眼合并白内障患者49例50眼，随机分成单切口组和双切口组，常规降眼压治疗后行白内障超声乳化人工晶状体植入联合小梁切除术，术前及术后分别采集泪液检测NO浓度，行激光闪辉细胞测量仪检测房水闪辉值。

结果：泪液NO浓度：术后NO浓度单切口组9.86±0.78 μmol/L，双切口组NO浓度为9.13±0.67μmol/L，单切口组高于双切口组，两组比较差异具有统计学意义(t=3.57，P<0.05)。房水闪辉值：术后单切口组62.42±18.16pc/ms，双切口组为52.20±17.57pc/ms，两组比较差异具有统计学意义(t=2.02，P<0.05)。

结论：双切口白内障超声乳化人工晶状体植入联合小梁切除术的早期炎性损伤低，具有安全性，但仍应提高手术技巧，减少手术创伤。

METHODS: Totally 49 patients(50 eyes)with primary acute angle-closure glaucoma and cataract were randomly divided to single-incision group and double-incision group. Both were treated by phacoemulsification and intraocular lens implantation and trabeculectomy after routine IOP-lowering drugs treatment. Preoperative and postoperative NO levels in tears were compared, and the aqueous flare and cells were examined using a laser flare-cell meter(LFCM).

RESULTS: Postoperative tear NO was 9.86±0.78μmol/L in single-incision group,it was 9.13±0.67μmol/L in double-incision group, the differences was statistically significant(t=3.57,P<0.05). Postoperative aqueous flare values was 62.42±18.16 pc/ms in single-incision group; it was 52.20±17.57 pc/ms in double-incision group,the differences was statistically significant(t=2.02, P<0.05).

CONCLUSION: The early inflammatory injury of double-incision was significantly lower than that of single-incision. It has the advantages of safety. But the surgical skill should be improved to less the injuries caused by operations.