方法：前瞻性随机对照试验。选取60位来自马来西亚贝尼苏夫大学与法尤姆大学医学院的患者随机分为6组(每组10位患者)。第一组：口服复合避孕药； 第二组：每月注射复合避孕剂(Mesocept)； 第三组：注射甲羟孕酮(Depo-Provera)； 第四组：仅服用黄体酮药片； 第五组：皮下埋植(Implanon)； 第六组：对照组。所有患者均进行全面妇科和眼科检查，包括Schirmer试验和泪膜破裂时间，随访至少3mo。

结果：所有患者的平均年龄为31.03±6.97岁。年龄和孕产次各组之间差异无统计学意义。结果显示：口服复合避孕药干眼患病率最高，其次是每月注射复合避孕剂、注射甲羟孕酮、仅服用黄体酮药片和皮下埋植。对照组无干眼患者。

结论：与仅含有孕激素的避孕方法相比，同时含有雌激素和孕激素的避孕方法导致干眼的可能性更大。

METHODS: Prospective randomized study was carried out in Faculty of medicine, Beni Suef University and Fayoum University. Sixty patients were divided into 6 groups(each group contain 10 patients): 1)combined oral pills; 2)combined monthly injection; 3)Depo-Provera injection; 4)progesterone only pills; 5)sub dermal Implanon; 6)control. All cases underwent full gynecological and ophthalmological examinations including Schirmer test and tear film break-up time(BUT)and followed up for at least 3mo.

RESULTS: The mean age of all the patients was 31.03±6.97y. There was no statistical significance between the groups in relation to age, parity and gravidity. The combined pills showed the highest percentage for dry eye followed by Mesocept then Depo-Provera then progesterone only pills then Implanon and no dry eyes in the control group.

CONCLUSION: Contraceptive methods containing both estrogen and progesterone are more likely to have dry eye than those who used progesterone only contraceptive methods.