方法：通过计算机检索CNKI、万方全文数据库、维普文献数据库收录的玻璃体切除手术与眼内填充物的随机对照和回顾性对照临床试验。在得到相关文献后，我们按照预先设定的标准纳入能够用来做分析的数据。最后，采用Comprehensive meta-analysis software version 2软件进行Meta分析，以评估针对眼内填充物修复视网膜脱离的有效性和安全性。

结果：纳入分析的文献有36篇，共计5 092眼。Meta分析结果显示：(1)玻璃体切除术后修复视网膜脱离所采用的眼内填充物，硅油的视网膜修复效果比C₃F₈和SF₆都好，且有统计学意义(OR=1.76，95% CI：1.19～2.60，P=0.0047； OR=4.68，95% CI：1.48～14.81，P=0.0087)。(2)在填充术后所引起的白内障风险上，硅油填充物明显高于BBS(OR=3.24，95% CI：2.10～4.99，P=1.09E-7)和C₃F₈(OR=3.03，95% CI：1.50～6.10，P=0.0019)。(3)在填充物增加术后眼压升高风险上，硅油比BBS具有显著升高的风险(OR=6.74，95% CI：3.38～13.41，P=5.67E-08)，同时C₃F₈也比BBS具有显著升高的风险(OR=4.79，95% CI：2.37～9.68，P=1.29E-05)。另外，硅油与重硅油相比风险则显著得小一些(OR=0.16，95% CI：0.08～0.53，P=0.0026)。

结论：治疗视网膜脱离的玻璃体视网膜手术所采用的眼内填充物，主要分为液体和气体两大类； 其中以硅油为主的液体填充物在修复视网膜脱离的有效率高于以C₃F₈和SF₆为主的气体。但是硅油填充术后并发症风险高于其他类型的眼内填充物。

METHODS: We performed a comprehensive search for studies reporting vitreous surgery with intraocular implants randomized controlled and a retrospective controlled clinical trials from China Hownet(CNKI), Wanfang database, and VIP literature database. Studies obtained from those database were filtered according to the criteria, and data were retrieved from eligible studies for further analysis. Then we performed a meta-analysis to evaluate the efficacy and safety of intraocular implants using comprehensive Meta-analysis software version 2(Biostat, Englewood, NJ).

RESULTS: In total 36 studies were recruited for our Meta-analysis, including 5 092 cases. Meta analysis showed: 1)regarding the efficacy of repairing the retinal detachment, silicone oil was a better intraocular implants than C₃F₈(OR=1.76; 95% CI: 1.19-2.60, P=0.0047)and SF₆(OR= 4.68; 95% CI: 1.48-14.81, P=0.0087); 2)regarding the risk of postoperative cataract, silicone oil showed significant higher risk than BBS(OR=3.24; 95% CI: 2.10-4.99, P=1.09 e-7), and C₃F₈(OR=3.03; 95% CI: 1.50-6.10, P=0.0019); 3)regarding the risk of postoperative intraocular pressure, silicone oil showed significant higher risk than BBS(OR=6.74; 95% CI: 3.38-13.41, P=5.67 e-08), and C₃F₈ also showed a higher risk than BBS(OR=4.79; 95% CI: 2.37-9.68, P=1.29 e-05). In addition, silicone oil showed significant lower risk as compared with heavy silicone oil(OR=0.16; 95% CI: 0.08-0.53, P=0.0026).

CONCLUSION: The intraocular implants for the treatment of retinal detachment in vitreous retinal surgery are mainly divided into two major categories, liquid and gas implants. The silicone oil, a major liquid implant, shows higher efficacy in terms of treating retinal detachment than the gas implants. However, the silicone oil is associated with a higher risk of postoperative cataract and intraocular pressure as compared with gas implants.