目的：研究血管内皮生长因子(vascular endothelial growth factor，VEGF)和碱性成纤维细胞生长因子(basic fibroblast growth factor，bFGF)在蒙古族糖尿病患者视网膜病变中的表达，探讨其中在糖尿病视网膜病变(diabetic retinopathy，DR)发生过程中的作用。

方法：对2013-02/2015-02在内蒙古自治区人民医院眼科83例蒙古族糖尿病患者根据视网膜病变情况分为：无糖尿病视网膜病变患者(NDR组)25例、背景型糖尿病视网膜病变患者(NPDR组)31例、增殖型糖尿病视网膜病变患者(PDR组)27例。36例年龄匹配健康志愿者作为对照组。分别采集患者外周静脉血，采用ELISA法分别对血清中VEGF和bFGF的表达情况进行测定。

结果：蒙古族糖尿病患者血清中VEGF和bFGF的水平显著高于对照组； 三组蒙古族糖尿病患者中，PDR患者血清VEGF和bFGF水平高于NDR和NPDR组，差异具有统计学意义(P<0.05)，NPDR患者血清VEGF和bFGF水平又显著高于NDR(P<0.05)。

结论：高表达的VEGF和bFGF可能是蒙古族DR发生、发展的重要致病因素。

AIM: To investigate the changes of serum angiogenic factors including vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in Mongolia patients with diabetic retinopathy(DR)and to explore their roles in the progress of DR.

METHODS: Eighty-three patients with diabetes were divided into three groups according to the retinopathy, no DR group(NDR, 25 cases), background DR(NPDR, 31 cases)and proliferative DR group(PDR, 27 cases), and 36 age-matched healthy people(control group)were selected. Serum concentrations of VEGF and bFGF were measured using ELISA method.

RESULTS:In Mongolia patients with diabetes, the serum concentrations of VEGF and bFGF were higher than those in control group; the serum concentrations of VEGF and bFGF in PDR group was higher than those of NDR and NPDR group(P<0.05); the concentrations of VEGF and bFGF in NPDR group was higher than that of NDR group(P<0.05).

CONCLUSION: High level of VEGF and bFGF may be the important pathogenic factors for DR in Mongolia patients.

内蒙古自治区自然科学基金(No.2011BS1110)