[关键词]
[摘要]
DJ-1作为对氧化还原反应敏感的分子伴侣以及氧化应激传感器参与多种细胞内生命活动，在抵抗氧化应激、调控信号通路、调节基因转录及线粒体动态平衡中起重要作用，与多种疾病的发生、发展密切相关。近年来，DJ-1在眼病中的作用越来越受到研究者的注意，相继发现其在富克斯角膜内皮营养不良(Fuchs endothelial corneal dystrophy，FECD)、年龄相关性黄斑变性(age-related macular degeneration，AMD)中具有显著的抗氧化应激作用。本文主要综述了近年来DJ-1抗氧化应激机制在这两种疾病发生发展中的作用。
[Key word]
[Abstract]
DJ-1 has been reported to act as aredox-activated chaperone and sensor of oxidative stress participated in a variety of activities in cellular, playing an important role in resisting oxidative stress, regulating signaling pathways and gene transcription, and maintaining mitochondria dynamic balance. DJ-1 is closely related to the occurrence and development of various diseases. Recently, the effect of DJ-1 in eye diseases has drawn more attention, and researchers have found its significant role of resistance to oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy(FECD)and age-related macular degeneration(AMD).This review will state the mechanism of DJ-1 against oxidative stress and its role in the development of eye diseases.
[中图分类号]
[基金项目]
国家自然科学基金(No.81371054)
