[关键词]
[摘要]
视网膜母细胞瘤(retinoblastoma，Rb)是眼内常见恶性肿瘤之一，恶性程度高，危害大。传统的治疗方法破坏性强，预后不佳。低氧诱导因子-1α在Rb中高表达，影响肿瘤细胞的分化增殖及转移，参与血管生成拟态的生成，进而调控Rb的整个发生发展过程。本文将对低氧诱导因子-1α在Rb发生发展中的作用做一综述，以期为Rb的治疗开辟新的途径。
[Key word]
[Abstract]
Retinoblastoma is a common eye malignant tumor which has high degree of malignancy.The traditional treatment methods are destructive, and the prognosis is poor. Hypoxia-inducible factor-1α highly express in retinoblastoma and regulate the development and progression of retinoblastoma(by influencing the proliferation and differentiation of tumor cells and involving in the generation of vascular mimicry). This article reviewed the role of hypoxia inducible factor-1α in the development of retinoblastoma which will initiate a new avenue for the treatment of retinoblastoma.
[中图分类号]
[基金项目]
上海市卫生和计划生育委员会科研资助课题(No.201540304)
