方法：前瞻性随机对照研究。将2014-06/09在南京东南眼科医院近视眼科接受LASEK手术的患者100例200眼随机分为两组(各50例)。溴芬酸钠组术前3d、术后1wk给予1g/L溴芬酸钠滴眼液2次/d，对照组给予普拉洛芬滴眼液4次/d，在术后1、3、5d，1、3mo观察并记录眼部刺激症状分级、角膜上皮愈合时间、haze情况以及裸眼视力、眼压变化情况。手术前后差异的比较采用配对样本t检验，组间差异的比较采用独立样本t检验，等级资料比较采用非参数秩和检验。

结果：两组患者术后眼部刺激症状分布的差异无统计学意义(P=0.317)，两组患者术后不同时间的裸眼视力间差异无统计学差异(P>0.05)，术后角膜上皮愈合时间两组亦无统计学意义(P=0.551)。

结论：1g/L溴芬酸钠滴眼液对于缓解LASEK术后眼部刺激症状与使用普拉洛芬滴眼液效果相似。

METHODS: In the prospective, randomized and controlled study, 100 patients(200 eyes)undergoing LASEK were randomized into the bromfenac sodium group(100 eyes)and control group(100 eyes). Patients in bromfenac sodium group received bromfenac sodium hydrate ophthalmic solution eye drops twice a day in 3d before surgery and 2wk after surgery, while the patients from the control group were given proanoprofen eye drops 4 times a day in the same period. At 1, 3, 5d, 1 and 3mo after surgery, irritative symptoms grade, duration of irritation, time for corneal epithelial healing, cornel haze, uncorrected visual acuity and intraocular pressure(IOP)were observed and compared between the two groups. Quantitative data were analyzed using independent samples t-test and ranked data were statistically analyzed using the Mann-Whiteney rank sun test.

RESULTS: There was no significant difference between two groups in irritative symptoms grade(P=0.317), neither was existed between two groups in uncorrected visual acuity after surgery(P>0.05). There was no statistical significance in the time for corneal epithelial healing between two groups(P=0.551).

CONCLUSION: Bromfenac sodium eye drops(1g/L)can achieve the same therapeutic effect as pranoprofen eye drops after LASEK.