方法：根据手术治疗方案将近视患者420例817眼分为观察组(225例431眼)与对照组(195例386眼)，观察组采用SMILE术矫正，对照组采用前弹力层下准分子激光原位角膜磨镶术(SBK)矫正，现对比分析两组患眼的治疗效果及不良反应发生率。

结果：术后1wk，1、3mo，两组患眼裸眼视力等于或优于最佳矫正视力的百分率相比差异无统计学意义(P>0.05)。术前，术后1wk，1、3mo，两组患眼角膜后表面顶点高度相比差异无统计学意义(P>0.05)。术前、术后3mo，两组患眼泪膜破裂时间相比差异无统计学意义(P>0.05)； 术后1mo，观察组患眼泪膜破裂时间显著长于对照组(P<0.05)。术前、术后1、3mo，两组患眼SchirmerⅠ试验滤纸条湿润长度相比差异无统计学意义(P>0.05)。两组患眼术源性角膜前表面三叶草差、彗差、球差、总高阶像差相比差异无统计学意义(P>0.05)。

结论：SMILE术与SBK术矫正近视的疗效相当，但是前者术后早期有着较好的泪膜稳定性。

METHODS: According to surgical treatment options 420 patients with myopia patients were(817 had eyes)divided into observation group(225 patients, 431 affected eyes)and control group(195 patients, 386 affected eyes). The observation group was treated with SMILE surgery correction, control group was treated with Bowman's layer of excimer laser in situ angular membrane keratomileusis(SBK)correction. The therapeutic effect of patients in two groups and the incidence rate of adverse reaction were comparativel analyzed.

RESULTS: After 1wk, 1mo and 3mo, there were no significant differences between the two groups. The difference was not statistically significant(P>0.05). Before and 1wk, 1mo, 3mo after operation, two groups of patients with corneal surface vertex height difference was not statistically significant(P>0.05). There was no significant difference between the two groups(P>0.05)in the preoperative and postoperative 3mo, the rupture time of the observation group was significantly longer than that in the control group(P<0.05). Preoperative and postoperative 1mo, 3mo, the two groups had no significant difference in the wet length of the Schirmer I test paper(P>0.05). Four eyes of the two groups had eye surgery source of corneal before surface clover grass difference, coma, spherical aberration and total higher order aberration compared the difference was not statistically significant(P>0.05).

CONCLUSION: The curative effect of SMILE surgery is similar to SBK surgery for myopia, but the early postoperative had better tear film stability.