[关键词]
[摘要]
圆锥角膜以进行性角膜前突和变薄，导致不规则散光和视功能损害为特征。大量研究表明，基质金属蛋白酶(matrix metalloproteinases， MMPs)在圆锥角膜基质降解和变薄过程中起关键性作用。紫外光A/核黄素角膜交联术(corneal crosslinking， CXL)是近年来发展起来的唯一能够延缓甚至阻止圆锥角膜病情进展的保守治疗方法。CXL对角膜生物力学和结构的影响研究较多，而对MMPs的影响研究较少。研究表明，CXL后患者泪液中的MMPs出现变化，而对基质中MMPs的影响尚无报道。进一步研究CXL后MMPs的变化有助于理解CXL后圆锥角膜的病理生理进程，以及CXL稳定圆锥角膜病情的作用机制。
[Key word]
[Abstract]
Keratoconus is characterized by progressive corneal thinning and protrusion, resulting in irregular astigmatism and visual impairment. Numerous studies show that matrix metalloproteinases(MMPs)play a key role in matrix degradation and thinning process. Corneal crosslinking(CXL)is a recently developed noninvasive treatment method which can delay or even prevent progression of keratoconus. Most studies focused on effect of CXL on corneal biomechanics and structure, but less on MMPs. Researches have shown that MMPs in tears of patients with keratoconus after CXL change, however alterations of those in corneal matrix remain unclear. Further study on the changes of MMPs after CXL is helpful to understand pathophysiological processes of postoperative keratoconus and mechanism of CXL stabilizing course of keratoconus.
[中图分类号]
[基金项目]
北京市科技计划课题(No.Z151100004015217)
