方法：纳入经门诊确诊为重度NPDR患者120例226眼，采用随机数字表分为治疗组和对照组。治疗组采取全视网膜光凝术联合口服和血明目片3mo，而对照组只行全视网膜激光光凝治疗。分别观察光凝术后的1、2、3mo时两组患者视功能、眼底视网膜出血、渗出、水肿等情况，同时记录两组患者光凝术后3mo眼底荧光血管造影情况。

结果：两组患者在光凝治疗术后1、2mo时，治疗组患者患眼视功能恢复情况显著优于对照组，差异具有统计学意义(P<0.05)。光凝术后3mo时，治疗组与对照组患眼视功能指标之间却无显著性区别，但与对照组相比，治疗组患者在眼底渗出、视网膜出血以及水肿消退方面具有显著性优势， 差异具有统计学意义(P<0.05)。

结论：对重度NPDR患者采用激光联合和血明目片进行治疗，可有效地缩短患眼视功能指标恢复速度，并可以促进视网膜出血及渗出的吸收速度，减少激光继发再损伤有一定的作用。

METHODS: A total of 120 patients(226 eyes)diagnosed by the clinic for severe non-proliferative diabetic retinopathy diabetic retinopathy patients were randomly divided into treatment group and control group. The patients underwent combined therapy defined as treatment group(Group A), the treatment process and took He xue ming mu tablets orally for 1-3mo defines a separate line. The patients with laser photocoagulation treatment as the control group(Group B). After 1, 2 and 3mo after treatment, the retinal hemorrhage and visual function of the patients in the two groups were observed, and the fundus fluorescein angiography in 3mo after treatment was observed.

RESULTS: Two groups of patients in the different treatment measures were taken after 1-2mo, patients suffering from eye visual function recovery was significantly better than the control group(P<0.05). But up to 2mo after the treatment, the treatment group and the control group eyes visual function index was no significant difference. Compared with the control group, the patients in the treatment group had significant advantages in terms of retinal hemorrhage, exudation, edema and fundus(P<0.05).

CONCLUSION: The severe non-proliferative diabetic retinopathy diabetic retinopathy treated by laser combined with He xue ming mu tablets treatment, can effectively shorten the eyes with visual function recovery speed, and can promote the absorption of retinal hemorrhage and exudation rate, reduce the secondary damage to the laser has a certain role.