方法：选取2013-03/2015-03在我院治疗的80例90眼视频终端顽固性干眼症患者为观察对象，采用前瞻性随机对照研究方法，根据软件SAS9.2形成一组随即数字，随机化分为对照组和观察组，对照组40例44眼，观察组40例46眼。对照组给予滴眼药治疗，观察组给予泪道栓子治疗，一个疗程30d，总共治疗3个疗程。观察并比较两组患者治疗前后泪液分泌试验和泪膜破裂时间以及症状积分。

结果：观察组治疗显效和有效的眼数明显多于对照组，治疗无效的眼数少于对照组，观察组治疗的总有效率高于对照组，差别具有统计学意义(P<0.05)； 两组患者治疗前的泪液分泌试验和泪膜破裂时间无明显差别，治疗后两组患者的上述指标均升高，而观察组升高更为明显，差别具有统计学意义(P<0.05)； 治疗前两组患者的干涩感、异物感、视疲劳和症状总分无明显差别，治疗后两组患者的上述指标均降低，且观察组降低更为明显，差别具有统计学意义(P<0.05)。

结论：泪道栓子对视频终端顽固性干眼症有较好的治疗效果，可明显改善患者的临床症状，具有良好的临床应用价值。

METHODS:A total of 80 patients with video terminals resistant dry eyes were selected in our hospital between Mar.2013 to Mar.2015. A prospective randomized controlled study used the software SAS9.2. All the patients were randomly divided into control group and observation group, 40 patients in each group. The control group treated with drops of ophthalmic, observation group treated with lacrimal duct embolus. A course included 30d, a total of 3 courses were in the treatment. The two groups before and after treatment in patients with tear secretion test and integral-rupture time and symptoms were observed and compared.

RESULTS: Observation group number of therapy effective and efficient eye were significantly larger than control group, and number of invalid eyes was less than that of control group, the total efficiency was higher than control group, the difference was statistically significant(P<0.05). Before treatment, the tear secretion test and tear film break-up time in two groups had no significant difference, after treatment, the above indexes of the two groups all increased, while observation group increased more significantly(P<0.05). Before treatment, scores of dry senses, foreign body sensation, visual fatigue and the total scores of symptoms in the two groups had no significant difference. After treatment, the above indexes of the two groups all decreased and the observation group decreased more significantly(P<0.05).

CONCLUSION:Lacrimal plug has good treatment effect on the video terminal refractory dry eye, which can significantly improve the patient's clinical symptoms, with good clinical application value.