方法：选取2014-06/2015-07在我院行SMILE(43例86眼)与飞秒LASIK(47例94眼)的手术顺利且随访资料完整的患者，所有患者术前及术后1、6mo，1a均行平均泪膜破裂时间(average tear film break-up time，aBUT)、泪液分泌功能(Schirmer Ⅰ test，SⅠt)及Pentacam眼前节分析诊断仪等检查，比较并分析两种不同术式在术后1a泪膜及角膜生物力学稳定性方面是否存在差异。

结果：两组患者术前一般资料无差异，术后平均随访时间为14±1.92mo。两组患者在术前和术后1mo时aBUT和SⅠt值无显著性差异； 在术后6mo和1a时的aBUT值在两组间有差异性(P<0.05)； 两组间SⅠt值在术后6mo时有差异性，但到术后1a时两组间已无统计学差异。术后1a时SMILE组与飞秒激光组的角膜最薄点高度分别为4.11±2.35、4.21±2.09μm； 角膜顶点后表面高度分别为1.33±0.94，1.23±0.93μm。角膜最薄点与角膜顶点后表面高度值在术前及术后各时间点两组间均未显示统计学差异(P>0.05)。

结论：SMILE组术后远期在泪膜稳定性上优于飞秒Lasik组，两组患者术后远期在角膜生物力学稳定性方面未发现明显差异，均相对稳定。

METHODS:A total of 43 patients(86 eyes)with SMILE and 47 patients(94 eyes)with F-LASIK were chosen from Jun.2014 to Jul.2015, whose surgery all successfully and medical records were complete. Average tear film break-up time(aBUT), Schirmer Ⅰ test(SⅠt)and Pentacam were obtained before surgery and at 1, 6 and 12mo after surgery. The paired t-test were used to analyze the collected data.

RESULTS: There was no significant difference in age, central corneal thickness(CCT)and optometry before surgery. The mean fellow time after surgery was(14±1.92)mo. The values of aBUT and SⅠt was no significantly different in before surgery and 1mo after surgery. There was significantly different in aBUT between 2 groups in 6 and 12mo after surgery(P<0.05). The SⅠt value only show different in 6mo after surgery. After one year, the posterior elevation of the thinnest point in SMILE and F-LASIK were(4.11±2.35)μm,(4.21±2.09)μm. The data of the central point were(1.33±0.94)μm,(1.23±0.93)μm. Whatever preparation or long time after surgery, there was no significantly different in 2 groups(P>0.05).

CONCLUTION: SMILE surgeries have superiority over F-LASIK in tear film stability. There is no change in corneal biomechanics, the posterior corneal surface is stable for long- term after SMILE or F-LASIK.