[关键词]
[摘要]
目的：通过对糖尿病与非糖尿病患者干眼症的症状及各项临床指标的综合分析，初步探讨糖尿病干眼症的临床特点。
方法：选取干眼症患者90例180眼，其中非糖尿病患者45例90眼，经内科确诊为2型糖尿病的干眼症患者45例90眼，对两组患者分别进行眼表疾病指数量表中文版(COSDI)问卷调查、泪膜破裂时间(BUT)、泪液分泌试验(Schirmer Ⅰ test)、角膜荧光素染色(FL)指标的测定，对两组结果进行统计学分析。
结果：两组干眼症指标比较，糖尿病组干眼症OSDI指数(46.88±18.51)高于非糖尿病组(39.76±13.62)，差别有统计学意义(P <0.05)； 糖尿病组角膜荧光素染色评分(1.57±1.33分)高于非糖尿病组(1.19±0.82分)，差别有统计学意义(P <0.05)； 糖尿病组干眼症Schirmer Ⅰ试验(4.30±1.80mm/5min)低于非糖尿病组(4.80±1.52mm/5min)，差别有统计学意义(P <0.05)； 而在泪膜破裂时间中，两组比较差别无统计学意义(P>0.05)。
结论：糖尿病组干眼症在症状、泪液的基础分泌及角膜上皮缺损方面均较非糖尿病组严重。对糖尿病患者的眼部筛查应包括干眼相关临床指标的检查，以便对糖尿病干眼患者提供及时有效的建议和治疗，改善其干眼症状，以提高其生活质量。
[Key word]
[Abstract]
AIM: To discuss the clinical features of dry eye in diabetics according to the comprehensive analysis of clinical symptoms and the clinical index on dry eye in diabetics and non-diabetics.
METHODS: Ninety patients with dry eye were collected from Jun.2014 to Feb.2016 in our hospital. A total of 45 cases of patients(90 eyes)with dry eye in diabetics and 45 cases of patients(90 eyes)with dry eye in non-diabetics were included. Patients in the two groups were provided with questionnaire survey of ocular surface disease index scale Chinese Version(COSDI). And tear break-up time(BUT), Schirmer Ⅰ test(Schirmer Ⅰ), corneal fluorescein staining(FL)were measured.
RESULTS:The OSDI index of dry eye in the diabetic group(46.88±18.51)was higher than that in the non-diabetic group(39.76±13.62). The difference was statistically significant(P<0.05). The corneal fluorescein staining score(1.57±1.33)in the diabetic group was higher than that in the non-diabetic group(1.19±0.82). The difference was statistically significant(P<0.05). The value of Schirmer Ⅰ test in the diabetic group(4.30±1.80)was lower than that in the non-diabetic group(4.80±1.52). The difference was statistically significant(P<0.05). The different value of BUT between two groups was not statistically significant(P>0.05).
CONCLUSION: Based on symptoms, tear secretion and corneal epithelial defects, the influence is more serious inthe diabetic group than that in the non-diabetic group. Eye screening in patients with diabetes mellitus should include dry eye related clinical indexes of examination. So the patients with dry eye in diabetics would be provided timely and effective suggestion and treatment. The symptoms of dry eye and the quality of life would be improved.
[中图分类号]
[基金项目]
福建省中医药科研项目(No.wzhw201305)
