目的：应用可视化角膜生物力学分析仪(Corvis ST)及眼反应分析仪(ORA)评估飞秒激光制瓣准分子激光原位角膜磨镶术(laser in situ keratomileusis，LASIK)术后角膜生物力学变化，并分析与其他参数的相关性。

方法：收集63例飞秒制瓣LASIK手术患者，所有收集对象采用右眼数据进行分析。角膜生物力学测量仪器应用可视化角膜生物力学分析仪Corvis ST及眼反应分析仪ORA，手术前及手术后1mo进行生物力学数据采集分析。配对t检验或Mann-Whitney U检验进行手术前后生物力学对比分析。Pearson 或Spearman统计学方法进行相关性分析。

结果：与FS-LASIK手术前相比，手术后1^st A-time，Vin，2^nd A length，Vout以及 Radius 下降，有统计学差异(P=0.00， P=0.00， P=0.00， P=0.00， P=0.00)。2^nd A-time，DA以及PD手术后增加，有统计学差异(P=0.00， P=0.00， P=0.00)。1^st A length以及HC time 手术后改变不明显，无统计学差异(P=0.96，P=0.08)。与FS-LASIK手术前相比，手术后CH，CRF下降，有统计学差异(P=0.00， P=0.00)。手术后1^st A-time， 2^nd A-time， DA and Radius变化量与手术前角膜中央厚度有明显相关性(P=0.01， P=0.04， P=0.03， P=0.01)。

结论：飞秒激光LASIK手术后角膜生物力学参数有较明显改变，可通过Corvis ST 及ORA生物力学参数计算得出相应变化，手术后生物力学参数变化与角膜厚度相关性明显。

AIM: To investigate the changes of corneal biomechanical properties before and after femtosecond laser assisted LASIK(FS-LASIK)using Corneal Visualisation Scheimpflug Technology(Corvis ST)and Ocular Response Analyzer(ORA), and the correlation with other myopic parameters.

METHODS:Sixty three patients(63 eyes)who had myopic femtosecond laser assisted LASIK(FS-LASIK)were enrolled in the study. The right eye of each patient was analyzed in this study. The corneal biomechanical parameters pre-operative and 1mo post-operative was measured with the Corvis ST(Oculus, Wetzlar, Germany)and ORA(Reichert, Buffalo, New York, USA). Comparison of the biomechanical property values before and after surgery was peformed using Paired t-test or Mann-Whitney U. Pearson or Spearman correlations were used to evaluate the relationship between parameters.

RESULTS: The postoperative 1^st A-time, Vin, 2^nd A length, Vout, HC time and Radius demonstrate significant decreases comparing with preoperative values(P=0.00, P=0.00, P=0.00, P=0.00, P=0.00, P=0.00 respectively). The postoperative 2^nd A-time, DA and PD significantly increases(P=0.00, P=0.00, P=0.00), however, the 1^st A length had no significant difference after surgery. The CH and CRF were significantly lower after FS-LASIK(P=0.00, P=0.00). A statistically significant correlation coefficient was found between preoperative central corneal thickness(CCT)with postoperative-preoperative changes of 1^st A-time, 2^nd A-time, DA and Radius respectively(P=0.01, P=0.04, P=0.03, P=0.01).

CONCLUSION:There were significantly changes of corneal biomechanical properties after FS-LASIK surgery. The changes of corneal biomechanical properties after FS-LASIK can be reflected by some parameters of Corvis ST and ORA. The mainly influence of corneal biomechanical alteration was possibly correlation with corneal thickness.

西安市社会发展引导项目 \〖No.SF1513(2)\〗; 陕西省社会发展项目(No.2016SF-274); 陕西卫生科研项目(No.2016E002)