[关键词]
[摘要]
核转录因子κB(nuclear factor-kappa B，NF-κB)是一种几乎存在于所有细胞中具有多向、多效调控作用的核转录因子。它可参与调控细胞的增生、分化、黏附、凋亡、炎症反应和免疫应答等生理病理过程，在机体的生长发育、炎症反应、免疫应答和肿瘤生长等方面发挥重要的作用。近些年的研究表明，NF-κB在眼科相关疾病的发病机制中占有重要的地位，尤其是眼表疾病、白内障、青光眼、葡萄膜炎、眼底疾病等，针对NF-κB活化的抑制可能成为眼科疾病治疗的新型靶点。本文将对NF-κB在眼科领域的研究报道进行综述。
[Key word]
[Abstract]
Nuclear factor-kappa B(NF-κB)is a nuclear transcription factor with multi-directional and multi-effect regulation, existing in almost all cells. It participates in the regulation of physiological and pathological processes, such as cell proliferation, differentiation, adhesion, apoptosis, inflammation and immune response, and plays an important role in body growth and development, inflammation, immune response, tumor growth and other aspects. In recent years, studies have indicated that NF-κB occupies an important place in the pathogenesis of eye related diseases, especially in ocular surface disease, cataract, glaucoma, uveitis, ocular fundus diseases and so on. There is a possibility that inhibition of NF-κB activation may become a novel target for the treatment of eye diseases. This paper will review the research reports of NF-κB in the field of ophthalmology.
[中图分类号]
[基金项目]
2013年哈尔滨市应用技术研究与开发项目(No.2013RFXYJ004)
