方法：收集鼻泪管阻塞患者279例，所有研究对象术前行泪道冲洗、泪道CT造影、鼻内镜检查。279例患者均行泪道激光成型+置管术，A组137例患者术后抗生素及非甾体抗炎药滴眼液点眼，B组142例患者术后抗生素及非甾体抗炎药滴眼液点眼联合赛洛唑啉鼻喷雾剂喷鼻治疗。

结果：参与研究的279例患者中，有217例(77.8%)患者鼻腔有炎症表现，其中A组105例(76.6%)，B组112例(78.9%)，主要为鼻腔黏膜充血、下鼻甲肥大、中鼻甲肥大等。拔管3mo后，A组137例患者有效率为86.1%，B组142例患者有效率为95.8%，差异有统计学意义(P<0.05)。

结论：鼻腔炎症是鼻泪管阻塞发病的重要因素，在泪道阻塞的诊疗过程中，临床医生需重视鼻腔炎症的治疗，泪道激光成型+人工鼻泪管置入术联合盐酸赛洛唑啉鼻用喷雾剂喷鼻治疗鼻泪管阻塞可明显提高鼻泪管阻塞的治愈率。

METHODS: Totally 279 patients with nasolacrimal duct obstruction were collected, who received lacrimal passage irrigation, CT angiography for lacrimal passage and nasal endoscope before treated by lacrimal laser forming and artificial nasolacrimal duct implantation combined with xylometazoline hydrochloride nasal spray. In group A, 137 patients were treated with antibiotic eye drop and non-steroidal anti-inflammatory drugs after operations. In group B, 142 patients were treated with xylometazoline hydrochloride nasal spray besides the same treatment for group A.

RESULTS:In the 279 patients 217(77.8%), in which 105 cases(76.6%)were in group A and 112 cases(78.9%)were in group B, were suffered with nasal inflammation, including nasal mucosal hyperemia, inferior turbinate hypertrophy, middle turbinate hypertrophy. At 3mo after the ducts were drawn, efficacy of group B was 95.8%, which was significant better than that of group A(86.1%, P<0.05).

CONCLUSION: Nasal inflammation was an important factor in the incidence of nasolacrimal duct obstruction, which shoud pay more attention in the process of diagnosis and treatment. Combination therapy could improve the cure rate of nasolacrimal duct obstruction.