[关键词]
[摘要]
丝裂原活化蛋白激酶(MAPK)信号转导通路家族是一条重要的信号转导通路，在细胞内广泛存在，可对细胞外的多种信号或刺激，如渗透压的改变、缺血再灌注、炎症反应等作出特定的生理反应，即介导细胞的分裂，分化或凋亡。MAPK通路所介导的生理反应对眼部创伤及其修复具有重要意义，家族中的多条通路能相互协作并对不同甚至相同的刺激作出不同的响应，因此在进行相关研究时需要对此加以重视。
[Key word]
[Abstract]
Mitogen-activated protein kinase(MAPK)signal pathway family are important signal transduction pathways, which widely exit in cells. They are able to make particular physiological responses induced by multiple extracellular signals or stimulus, such as changes of osmotic pressures, ischemic/reperfusion, inflammation and so on, that means they can mediate cell proliferation, differentiation and apoptosis. The physiological responses mediated by MAPK signal pathway make great scene to the progression and healing of eye wounds, therefore researchers may highlight the pathway in research.
[中图分类号]
[基金项目]
吉林大学白求恩支持计划(No.470110000520); 吉林大学优秀青年教师培养计划(No.419080500586)
